Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study
BACKGROUND: Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS: Over 0.5 million adults aged 30 to 79 y...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Heart Association
2016
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| _version_ | 1797050353998364672 |
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| author | Liu, N Pan, X Yu, C Lv, J Guo, Y Bian, Z Yang, L Chen, Y Wu, T Chen, Z Pan, A Li, L China Kadoorie Biobank Collaborative Group |
| author_facet | Liu, N Pan, X Yu, C Lv, J Guo, Y Bian, Z Yang, L Chen, Y Wu, T Chen, Z Pan, A Li, L China Kadoorie Biobank Collaborative Group |
| author_sort | Liu, N |
| collection | OXFORD |
| description | BACKGROUND: Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS: Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004-2008) until December 31, 2013. Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview-Short Form at baseline. Incident IHD cases were identified through linkage to related medical databases, and defined as having International Statistical Classification of Diseases and Related Health Problems 10th Revision codes of I20 to I25. Cox proportional hazards regression models were used to estimate hazard ratios and 95% CIs for the MD-IHD association with adjustment for sociodemographic variables and established cardiovascular risk factors. During 3 423 542 person-years of follow-up, 24 705 incident IHD cases were documented. Higher IHD incidence was observed in participants with MD compared with those without (8.76 versus 7.21 per 1000 person-years), and the multivariable-adjusted hazard ratio was 1.32 (95% CI 1.15-1.53). Geographic location modified the association (P for interaction=0.005), and a positive association was observed in urban residents (hazard ratio 1.72; 95% CI 1.39-2.14) but not rural residents (1.13; 0.93-1.37). Compared with participants without depressive symptoms, the hazard ratio (95% CI) of IHD was 1.13 (1.04-1.23) for those with depressive symptoms only and 1.33 (1.15-1.53) for those with MD. CONCLUSIONS: Past year major depression was associated with an increased risk of IHD in Chinese adults, independent of other major cardiovascular risk factors. |
| first_indexed | 2024-03-06T18:03:53Z |
| format | Journal article |
| id | oxford-uuid:00c20246-b18f-464a-ae58-98158b5efdb0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:03:53Z |
| publishDate | 2016 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:00c20246-b18f-464a-ae58-98158b5efdb02022-03-26T08:31:16ZAssociation of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank StudyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:00c20246-b18f-464a-ae58-98158b5efdb0EnglishSymplectic Elements at OxfordAmerican Heart Association2016Liu, NPan, XYu, CLv, JGuo, YBian, ZYang, LChen, YWu, TChen, ZPan, ALi, LChina Kadoorie Biobank Collaborative GroupBACKGROUND: Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS: Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004-2008) until December 31, 2013. Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview-Short Form at baseline. Incident IHD cases were identified through linkage to related medical databases, and defined as having International Statistical Classification of Diseases and Related Health Problems 10th Revision codes of I20 to I25. Cox proportional hazards regression models were used to estimate hazard ratios and 95% CIs for the MD-IHD association with adjustment for sociodemographic variables and established cardiovascular risk factors. During 3 423 542 person-years of follow-up, 24 705 incident IHD cases were documented. Higher IHD incidence was observed in participants with MD compared with those without (8.76 versus 7.21 per 1000 person-years), and the multivariable-adjusted hazard ratio was 1.32 (95% CI 1.15-1.53). Geographic location modified the association (P for interaction=0.005), and a positive association was observed in urban residents (hazard ratio 1.72; 95% CI 1.39-2.14) but not rural residents (1.13; 0.93-1.37). Compared with participants without depressive symptoms, the hazard ratio (95% CI) of IHD was 1.13 (1.04-1.23) for those with depressive symptoms only and 1.33 (1.15-1.53) for those with MD. CONCLUSIONS: Past year major depression was associated with an increased risk of IHD in Chinese adults, independent of other major cardiovascular risk factors. |
| spellingShingle | Liu, N Pan, X Yu, C Lv, J Guo, Y Bian, Z Yang, L Chen, Y Wu, T Chen, Z Pan, A Li, L China Kadoorie Biobank Collaborative Group Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study |
| title | Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study |
| title_full | Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study |
| title_fullStr | Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study |
| title_full_unstemmed | Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study |
| title_short | Association of major depression with risk of ischemic heart disease in a mega-cohort of Chinese adults: the China Kadoorie Biobank Study |
| title_sort | association of major depression with risk of ischemic heart disease in a mega cohort of chinese adults the china kadoorie biobank study |
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