The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.

OBJECTIVES: This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselec...

Full description

Bibliographic Details
Main Authors: Abizaid, A, Costa, JR, Banning, A, Bartorelli, A, Dzavik, V, Ellis, S, Gao, R, Holmes, DR, Jeong, M, Legrand, V, Neumann, F, Nyakern, M, Orlick, A, Spaulding, C, Worthley, S, Urban, P
Format: Journal article
Language:English
Published: 2012
_version_ 1797050355390873600
author Abizaid, A
Costa, JR
Banning, A
Bartorelli, A
Dzavik, V
Ellis, S
Gao, R
Holmes, DR
Jeong, M
Legrand, V
Neumann, F
Nyakern, M
Orlick, A
Spaulding, C
Worthley, S
Urban, P
author_facet Abizaid, A
Costa, JR
Banning, A
Bartorelli, A
Dzavik, V
Ellis, S
Gao, R
Holmes, DR
Jeong, M
Legrand, V
Neumann, F
Nyakern, M
Orlick, A
Spaulding, C
Worthley, S
Urban, P
author_sort Abizaid, A
collection OXFORD
description OBJECTIVES: This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselected, real-world patients. BACKGROUND: There is paucity of consistent data on DES for the treatment of ISR, especially, DES ISR. METHODS: The e-SELECT (Multicenter Post-Market Surveillance) registry is a Web-based, multicenter and international registry encompassing virtually all subsets of patients and lesions treated with at least 1 SES during the period from 2006 to 2008. We enrolled in this pre-specified subanalysis all patients with at least 1 clinically relevant BMS or DES ISR treated with SES. Primary endpoint was major adverse cardiac events and stent thrombosis rate at 1 year. RESULTS: Of 15,147 patients enrolled, 1,590 (10.5%) presented at least 1 ISR (BMS group, n = 1,235, DES group, n = 355). Patients with DES ISR had higher incidence of diabetes (39.4% vs. 26.9%, p < 0.001), renal insufficiency (5.8% vs. 2.3%, p = 0.003), and prior coronary artery bypass graft (20.5% vs. 11.8%, p < 0.001). At 1 year, death (1.4% for BMS vs. 2.1% for DES, p = 0.3) and myocardial infarction (2.4% for BMS and 3.3% for DES, p = 0.3) rates were similar, whereas ischemia-driven target lesion revascularization and definite/probable late stent thrombosis were higher in patients with DES ISR (6.9% vs. 3.1%, p = 0.003, and 1.8% vs. 0.5%, p = 0.04, respectively). CONCLUSIONS: Use of SES for either BMS or DES ISR treatment is safe and associated with low target lesion revascularization recurrence and no apparent safety concern.
first_indexed 2024-03-06T18:03:54Z
format Journal article
id oxford-uuid:00c5c297-5a7a-4254-b786-56e1ac3ef10d
institution University of Oxford
language English
last_indexed 2024-03-06T18:03:54Z
publishDate 2012
record_format dspace
spelling oxford-uuid:00c5c297-5a7a-4254-b786-56e1ac3ef10d2022-03-26T08:31:21ZThe sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:00c5c297-5a7a-4254-b786-56e1ac3ef10dEnglishSymplectic Elements at Oxford2012Abizaid, ACosta, JRBanning, ABartorelli, ADzavik, VEllis, SGao, RHolmes, DRJeong, MLegrand, VNeumann, FNyakern, MOrlick, ASpaulding, CWorthley, SUrban, POBJECTIVES: This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselected, real-world patients. BACKGROUND: There is paucity of consistent data on DES for the treatment of ISR, especially, DES ISR. METHODS: The e-SELECT (Multicenter Post-Market Surveillance) registry is a Web-based, multicenter and international registry encompassing virtually all subsets of patients and lesions treated with at least 1 SES during the period from 2006 to 2008. We enrolled in this pre-specified subanalysis all patients with at least 1 clinically relevant BMS or DES ISR treated with SES. Primary endpoint was major adverse cardiac events and stent thrombosis rate at 1 year. RESULTS: Of 15,147 patients enrolled, 1,590 (10.5%) presented at least 1 ISR (BMS group, n = 1,235, DES group, n = 355). Patients with DES ISR had higher incidence of diabetes (39.4% vs. 26.9%, p < 0.001), renal insufficiency (5.8% vs. 2.3%, p = 0.003), and prior coronary artery bypass graft (20.5% vs. 11.8%, p < 0.001). At 1 year, death (1.4% for BMS vs. 2.1% for DES, p = 0.3) and myocardial infarction (2.4% for BMS and 3.3% for DES, p = 0.3) rates were similar, whereas ischemia-driven target lesion revascularization and definite/probable late stent thrombosis were higher in patients with DES ISR (6.9% vs. 3.1%, p = 0.003, and 1.8% vs. 0.5%, p = 0.04, respectively). CONCLUSIONS: Use of SES for either BMS or DES ISR treatment is safe and associated with low target lesion revascularization recurrence and no apparent safety concern.
spellingShingle Abizaid, A
Costa, JR
Banning, A
Bartorelli, A
Dzavik, V
Ellis, S
Gao, R
Holmes, DR
Jeong, M
Legrand, V
Neumann, F
Nyakern, M
Orlick, A
Spaulding, C
Worthley, S
Urban, P
The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
title The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
title_full The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
title_fullStr The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
title_full_unstemmed The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
title_short The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
title_sort sirolimus eluting cypher select coronary stent for the treatment of bare metal and drug eluting stent restenosis insights from the e select multicenter post market surveillance registry
work_keys_str_mv AT abizaida thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT costajr thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT banninga thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT bartorellia thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT dzavikv thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT elliss thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT gaor thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT holmesdr thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT jeongm thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT legrandv thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT neumannf thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT nyakernm thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT orlicka thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT spauldingc thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT worthleys thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT urbanp thesirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT abizaida sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT costajr sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT banninga sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT bartorellia sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT dzavikv sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT elliss sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT gaor sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT holmesdr sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT jeongm sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT legrandv sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT neumannf sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT nyakernm sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT orlicka sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT spauldingc sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT worthleys sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry
AT urbanp sirolimuselutingcypherselectcoronarystentforthetreatmentofbaremetalanddrugelutingstentrestenosisinsightsfromtheeselectmulticenterpostmarketsurveillanceregistry