Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst.
The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor....
| Autors principals: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2002
|
| _version_ | 1826256569912786944 |
|---|---|
| author | Chobotova, K Spyropoulou, I Carver, J Manek, S Heath, J Gullick, W Barlow, D Sargent, I Mardon, H |
| author_facet | Chobotova, K Spyropoulou, I Carver, J Manek, S Heath, J Gullick, W Barlow, D Sargent, I Mardon, H |
| author_sort | Chobotova, K |
| collection | OXFORD |
| description | The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor. Here we demonstrate a potential function for the transmembrane form of heparin-binding epidermal growth factor in mediating blastocyst attachment to the endometrium, in two different novel in vitro models for human implantation. Furthermore, we demonstrate specific localisation of the heparin-binding epidermal growth factor receptor ErbB4, on the surface of the trophectoderm in peri-implantation human blastocysts. Our data lead the way for further dissection of the molecular mechanisms of implantation of the human embryo, and have implications for infertility, in vitro fertilization and contraception. |
| first_indexed | 2024-03-06T18:04:19Z |
| format | Journal article |
| id | oxford-uuid:00e947fe-e48a-477c-83c2-bca1063a7fd2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:04:19Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:00e947fe-e48a-477c-83c2-bca1063a7fd22022-03-26T08:32:00ZHeparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:00e947fe-e48a-477c-83c2-bca1063a7fd2EnglishSymplectic Elements at Oxford2002Chobotova, KSpyropoulou, ICarver, JManek, SHeath, JGullick, WBarlow, DSargent, IMardon, HThe mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate molecules that mediate and facilitate implantation have been identified in animal studies, and include heparin binding epidermal growth factor. Here we demonstrate a potential function for the transmembrane form of heparin-binding epidermal growth factor in mediating blastocyst attachment to the endometrium, in two different novel in vitro models for human implantation. Furthermore, we demonstrate specific localisation of the heparin-binding epidermal growth factor receptor ErbB4, on the surface of the trophectoderm in peri-implantation human blastocysts. Our data lead the way for further dissection of the molecular mechanisms of implantation of the human embryo, and have implications for infertility, in vitro fertilization and contraception. |
| spellingShingle | Chobotova, K Spyropoulou, I Carver, J Manek, S Heath, J Gullick, W Barlow, D Sargent, I Mardon, H Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. |
| title | Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. |
| title_full | Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. |
| title_fullStr | Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. |
| title_full_unstemmed | Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. |
| title_short | Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. |
| title_sort | heparin binding epidermal growth factor and its receptor erbb4 mediate implantation of the human blastocyst |
| work_keys_str_mv | AT chobotovak heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT spyropouloui heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT carverj heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT maneks heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT heathj heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT gullickw heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT barlowd heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT sargenti heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst AT mardonh heparinbindingepidermalgrowthfactoranditsreceptorerbb4mediateimplantationofthehumanblastocyst |