The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains.

The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains.

BACKGROUND: The Q151M multi-drug resistance (MDR) pathway in HIV-1 reverse transcriptase (RT) confers reduced susceptibility to all nucleoside reverse transcriptase inhibitors (NRTIs) excluding tenofovir (TDF). This pathway emerges after long term failure of therapy, and is increasingly observed in...

Full description

Bibliographic Details
Main Authors:	Mbisa, J, Gupta, R, Kabamba, D, Mulenga, V, Kalumbi, M, Chintu, C, Parry, C, Gibb, D, Walker, SA, Cane, P, Pillay, D
Format:	Journal article
Language:	English
Published:	2011

Similar Items

The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains
by: Gibb Diana M, et al.
Published: (2011-05-01)

Dynamics of emergence and linkage of HIV reverse transcriptase Q151M MDR complex in children within first-line antiretroviral rollout uncovered by single-genome sequencing
by: Mbisa, J, et al.
Published: (2009)

Identification of the phenotypic, genotypic and fitness correlates of non-B subtype HIV-1 NRTI resistance through longitudinal analysis of children with virological failure in the developing world
by: Mbisa, J, et al.
Published: (2010)

Coevolved Multidrug-Resistant HIV-1 Protease and Reverse Transcriptase Influences Integrase Drug Susceptibility and Replication Fitness
by: Supang A. Martin, et al.
Published: (2021-08-01)

Drug resistance in human immunodeficiency virus type-1 infected Zambian children using adult fixed dose combination stavudine, lamivudine, and nevirapine.
by: Gupta, R, et al.
Published: (2010)

K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.
by: Atsuko Hachiya, et al.
Published: (2011-01-01)

Dynamics of accumulation of drug resistance mutations in the absence of virological monitoring in HIV-1-infected Zambian children using adult Triomune (fixed-dose combination d4T, 3TC and NVP)
by: Gupta, R, et al.
Published: (2009)

The impact of daily cotrimoxazole prophylaxis and antiretroviral therapy on mortality and hospital admissions in HIV-infected Zambian children.
by: Walker, A, et al.
Published: (2007)

Pharmacokinetics of lopinavir-ritonavir with and without nonnucleoside reverse transcriptase inhibitors in Ugandan HIV-infected adults.
by: Kityo, C, et al.
Published: (2010)

Improved growth and anemia in HIV-infected African children taking cotrimoxazole prophylaxis.
by: Prendergast, A, et al.
Published: (2011)

Is nevirapine dose-escalation appropriate in young, African, HIV-infected children?
by: Fillekes, Q, et al.
Published: (2013)

Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets.
by: L'homme, R, et al.
Published: (2008)

Limited sampling models to predict the pharmacokinetics of nevirapine, stavudine, and lamivudine in HIV-infected children treated with pediatric fixed-dose combination tablets.
by: Burger, D, et al.
Published: (2010)

Pharmacokinetics of nevirapine in HIV-infected infants weighing 3 kg to less than 6 kg taking paediatric fixed dose combination tablets.
by: Fillekes, Q, et al.
Published: (2012)

Background Activity of Reverse Transcriptases
by: Angelica V. Timofeeva, et al.
Published: (2001-01-01)

A reverse transcriptase ribozyme
by: Biswajit Samanta, et al.
Published: (2017-09-01)

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo.
by: Haley D M Wyatt, et al.
Published: (2009-09-01)

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation
by: Bonté Frédéric, et al.
Published: (2009-09-01)

STRUCTURAL STUDIES ON HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE
by: Stammers, D, et al.
Published: (1990)

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.
by: Esnouf, R, et al.
Published: (1995)

Telomerase reverse transcriptase and neurodegenerative diseases
by: Xin Yu, et al.
Published: (2023-03-01)

THE GROWTH AND CHARACTERIZATION OF CRYSTALS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REVERSE-TRANSCRIPTASE
by: Jones, E, et al.
Published: (1993)

OF CADAVERIC PARTICLES AND REVERSE TRANSCRIPTASE LESSONS IN THE CONTROL OF HOSPITAL INFECTION
by: Mark D Zimmerman
Published: (2003-01-01)

The Molecular Docking of Specific Reverse Transcriptase Inhibitory Ligands onto the Molecular Model of HIV-1 Reverse Transcriptase
by: Roohallah Yousefi
Published: (2024-06-01)

Strategies for nevirapine initiation in HIV-infected children taking pediatric fixed-dose combination "baby pills" in Zambia: a randomized controlled trial.
by: Mulenga, V, et al.
Published: (2010)

Excellent adherence to antiretrovirals in HIV+ Zambian children is compromised by disrupted routine, HIV nondisclosure, and paradoxical income effects
by: Haberer, J, et al.
Published: (2011)

Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase.
by: Bird, L, et al.
Published: (2003)

Determinants of survival without antiretroviral therapy after infancy in HIV-1-infected Zambian children in the CHAP Trial.
by: Walker, A, et al.
Published: (2006)

HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis.
by: Lowe, D, et al.
Published: (1988)

Reverse transcriptase inhibitors from curcuma phaeocaulis/
by: Hou, Yu-Chi, et al.

Fluorometric Assay for DNA Polymerases and Reverse Transcriptase
by: Mark Seville, et al.
Published: (1996-10-01)

The regulations of telomerase reverse transcriptase (TERT) in cancer
by: Mingdi Liu, et al.
Published: (2024-01-01)

Comprehensive phylogenetic analysis of bacterial reverse transcriptases.
by: Nicolás Toro, et al.
Published: (2014-01-01)

The Reverse Transcriptases Associated with CRISPR-Cas Systems
by: Nicolás Toro, et al.
Published: (2017-08-01)

Adherence to both cotrimoxazole and placebo is associated with improved survival among HIV-infected Zambian children.
by: Walker, A, et al.
Published: (2009)

HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors
by: Nicolas Tardiota, et al.
Published: (2024-01-01)

Comparison of Reverse Transcriptase Loop-Mediated Isothermal Amplification and Reverse Transcriptase Polymerase Chain Reaction for Detection of Prostate Specific Antigen
by: Mohammad Amin Almasi, et al.
Published: (2019-01-01)

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.
by: Ren, J, et al.
Published: (1998)

A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance.
by: Harrigan, P, et al.
Published: (2002)

Structural characterization of HIV reverse transcriptase: a target for the design of specific virus inhibitors.
by: Tisdale, M, et al.
Published: (1989)