Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis

Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis

N-Butyl-deoxynojirimycin (NB-DNJ) has been approved for clinical trials as a potential therapy for Gaucher disease, a glycolipid lysosomal storage disorder. As this compound has both glycoprotein processing α-glucosidase and ceramide glucosyltransferase inhibitory activity, we have sought to determi...

Полное описание

Библиографические подробности
Главные авторы:	Butters, T, van den Broek, L, Fleet, G, Krulle, T, Wormald, M, Dwek, R, Platt, F
Формат:	Journal article
Язык:	English
Опубликовано:	2000

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