Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis

Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis

N-Butyl-deoxynojirimycin (NB-DNJ) has been approved for clinical trials as a potential therapy for Gaucher disease, a glycolipid lysosomal storage disorder. As this compound has both glycoprotein processing α-glucosidase and ceramide glucosyltransferase inhibitory activity, we have sought to determi...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Butters, T, van den Broek, L, Fleet, G, Krulle, T, Wormald, M, Dwek, R, Platt, F
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2000

Những quyển sách tương tự

Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells.
Bằng: Boomkamp, S, et al.
Được phát hành: (2010)

Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.
Bằng: Mellor, H, et al.
Được phát hành: (2003)

Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
Bằng: Butters, T, et al.
Được phát hành: (2000)

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
Bằng: Butters, T, et al.
Được phát hành: (2005)

Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.
Bằng: van der Spoel, A, et al.
Được phát hành: (2008)

Therapeutic applications of imino sugars in lysosomal storage disorders.
Bằng: Butters, T, et al.
Được phát hành: (2003)

N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo.
Bằng: Andersson, U, et al.
Được phát hành: (2000)

Imino sugar therapy for type 1 Gaucher disease.
Bằng: Priestman, D, et al.
Được phát hành: (2000)

Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.
Bằng: Andersson, U, et al.
Được phát hành: (2004)

Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
Bằng: Mellor, H, et al.
Được phát hành: (2004)

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.
Bằng: Butters, T, et al.
Được phát hành: (2003)

Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
Bằng: Jeyakumar, M, et al.
Được phát hành: (2002)

High-performance cation-exchange chromatography and pulsed amperometric detection for the separation, detection, and quantitation of N-alkylated imino sugars in biological samples.
Bằng: Mellor, H, et al.
Được phát hành: (2000)

SYNTHESIS OF 1,5-DIDEOXY-3-O-(ALPHA-D-MANNOPYRANOSYL)-1,5-IMINO-D-MANNITOL AND 1,5-DIDEOXY-3-O-(ALPHA-D-GLUCOPYRANOSYL)-1,5-IMINO-D-MANNITOL - POWERFUL INHIBITORS OF ENDOMANNOSIDASE
Bằng: Ardron, H, et al.
Được phát hành: (1993)

New developments in treating glycosphingolipid storage diseases.
Bằng: Platt, F, et al.
Được phát hành: (2005)

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol
Bằng: Harding, C, et al.
Được phát hành: (2005)

O-linked glycosylation in focus
Bằng: Van den Steen, P, et al.
Được phát hành: (2000)

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol 0.33-hydrate
Bằng: Harding, C, et al.
Được phát hành: (2005)

Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.
Bằng: van der Spoel, A, et al.
Được phát hành: (2002)

Modulation of THP-1 macrophage and cholesterol-loaded foam cell apolipoprotein E levels by glycosphingolipids.
Bằng: Garner, B, et al.
Được phát hành: (2002)

Glycosphingolipid profiling of tissues from mouse models of human lysosomal storage disorders
Bằng: Priestman, D, et al.
Được phát hành: (2008)

Glycosphingolipid disorders of the brain.
Bằng: Boomkamp, S, et al.
Được phát hành: (2008)

Substrate deprivation: a new therapeutic approach for the glycosphingolipid lysosomal storage diseases.
Bằng: Platt, F, et al.
Được phát hành: (2000)

Targeting glycosylation as a therapeutic approach.
Bằng: Dwek, R, et al.
Được phát hành: (2002)

Pharmacological impairment of acrosome formation and sperm head morphogenesis reveals essential role of glycosphingolipids in spermiogenesis
Bằng: van der Spoel, A, et al.
Được phát hành: (2002)

Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.
Bằng: Mehta, A, et al.
Được phát hành: (2001)

Control in the N-linked glycoprotein biosynthesis pathway.
Bằng: Butters, T
Được phát hành: (2002)

Alkylated imino sugars, reversible male infertility-inducing agents, do not change the genetic integrity of male mouse germ cells, despite severe deformities of spermatozoal structures.
Bằng: Suganuma, R, et al.
Được phát hành: (2004)

Glycosphingolipids in endocytic membrane transport.
Bằng: Sillence, D, et al.
Được phát hành: (2004)

Structural aspects of glycomes with a focus on N-glycosylation and glycoprotein folding.
Bằng: Petrescu, A, et al.
Được phát hành: (2006)

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
Bằng: D'Angelo, G, et al.
Được phát hành: (2007)

Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
Bằng: Suganuma, R, et al.
Được phát hành: (2005)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
Bằng: Zitzmann, N, et al.
Được phát hành: (1999)

Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling.
Bằng: Neville, D, et al.
Được phát hành: (2004)

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases
Bằng: Silk, J, et al.
Được phát hành: (2005)

Introduction: Glycosphingolipids in cell biology and disease.
Bằng: Sillence, D, et al.
Được phát hành: (2004)

Novel di-branched monosaccharides and imino sugars
Bằng: Barker, K, et al.
Được phát hành: (2009)

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
Bằng: Gadola, S, et al.
Được phát hành: (2006)

Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice.
Bằng: Garner, B, et al.
Được phát hành: (2002)

Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
Bằng: Pei, B, et al.
Được phát hành: (2011)