Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes.
The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmissi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
National Academy of Sciences
2018
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| _version_ | 1826256592870309888 |
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| author | Carrington, LB Tran, BCN Le, NTH Luong, TTH Nguyen, TT Nguyen, PT Nguyen, CVV Nguyen, HTC Vu, TT Vo, LT Le, DT Vu, NT Nguyen, GT Luu, HQ Dang, AD Hurst, TP O'Neill, SL Tran, VT Kien, DTH Nguyen, NM Wolbers, M Wills, B Simmons, CP |
| author_facet | Carrington, LB Tran, BCN Le, NTH Luong, TTH Nguyen, TT Nguyen, PT Nguyen, CVV Nguyen, HTC Vu, TT Vo, LT Le, DT Vu, NT Nguyen, GT Luu, HQ Dang, AD Hurst, TP O'Neill, SL Tran, VT Kien, DTH Nguyen, NM Wolbers, M Wills, B Simmons, CP |
| author_sort | Carrington, LB |
| collection | OXFORD |
| description | The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of wMel introgression for the biocontrol of Ae. aegypti-born arboviruses. |
| first_indexed | 2024-03-06T18:04:41Z |
| format | Journal article |
| id | oxford-uuid:010a33bd-07fa-4b3a-9389-99ff21e49543 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:04:41Z |
| publishDate | 2018 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:010a33bd-07fa-4b3a-9389-99ff21e495432022-03-26T08:32:42ZField- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:010a33bd-07fa-4b3a-9389-99ff21e49543EnglishSymplectic Elements at OxfordNational Academy of Sciences2018Carrington, LBTran, BCNLe, NTHLuong, TTHNguyen, TTNguyen, PTNguyen, CVVNguyen, HTCVu, TTVo, LTLe, DTVu, NTNguyen, GTLuu, HQDang, ADHurst, TPO'Neill, SLTran, VTKien, DTHNguyen, NMWolbers, MWills, BSimmons, CPThe wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of wMel introgression for the biocontrol of Ae. aegypti-born arboviruses. |
| spellingShingle | Carrington, LB Tran, BCN Le, NTH Luong, TTH Nguyen, TT Nguyen, PT Nguyen, CVV Nguyen, HTC Vu, TT Vo, LT Le, DT Vu, NT Nguyen, GT Luu, HQ Dang, AD Hurst, TP O'Neill, SL Tran, VT Kien, DTH Nguyen, NM Wolbers, M Wills, B Simmons, CP Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. |
| title | Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. |
| title_full | Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. |
| title_fullStr | Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. |
| title_full_unstemmed | Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. |
| title_short | Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. |
| title_sort | field and clinically derived estimates of wolbachia mediated blocking of dengue virus transmission potential in aedes aegypti mosquitoes |
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