Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris
Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multi...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature [academic journals on nature.com]
2024
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| _version_ | 1817930604152356864 |
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| author | Kappel, D Gifford, H Brackin, A Abdolrasouli, A Eyre, DW Jeffery, K Schlenz, S Aanensen, DM Brown, CS Borman, A Johnson, E Holmes, A Armstrong-James, D Fisher, MC Rhodes, J |
| author_facet | Kappel, D Gifford, H Brackin, A Abdolrasouli, A Eyre, DW Jeffery, K Schlenz, S Aanensen, DM Brown, CS Borman, A Johnson, E Holmes, A Armstrong-James, D Fisher, MC Rhodes, J |
| author_sort | Kappel, D |
| collection | OXFORD |
| description | Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of C. auris introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug-resistant C. auris are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of C. auris to protect patients and healthcare services. |
| first_indexed | 2024-12-09T03:08:46Z |
| format | Journal article |
| id | oxford-uuid:01163c88-b643-4aa3-8aba-f5199e83e7d0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:08:46Z |
| publishDate | 2024 |
| publisher | Springer Nature [academic journals on nature.com] |
| record_format | dspace |
| spelling | oxford-uuid:01163c88-b643-4aa3-8aba-f5199e83e7d02024-09-30T20:07:53ZGenomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida aurisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:01163c88-b643-4aa3-8aba-f5199e83e7d0EnglishJisc Publications RouterSpringer Nature [academic journals on nature.com]2024Kappel, DGifford, HBrackin, AAbdolrasouli, AEyre, DWJeffery, KSchlenz, SAanensen, DMBrown, CSBorman, AJohnson, EHolmes, AArmstrong-James, DFisher, MCRhodes, JCandida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of C. auris introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug-resistant C. auris are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of C. auris to protect patients and healthcare services. |
| spellingShingle | Kappel, D Gifford, H Brackin, A Abdolrasouli, A Eyre, DW Jeffery, K Schlenz, S Aanensen, DM Brown, CS Borman, A Johnson, E Holmes, A Armstrong-James, D Fisher, MC Rhodes, J Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris |
| title | Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris |
| title_full | Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris |
| title_fullStr | Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris |
| title_full_unstemmed | Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris |
| title_short | Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris |
| title_sort | genomic epidemiology describes introduction and outbreaks of antifungal drug resistant candida auris |
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