Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Εμφάνιση άλλων εκδόσεων (1)

Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Thalhammer, A, Mecinović, J, Loenarz, C, Tumber, A, Rose, N, Heightman, T, Schofield, C
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2011

Παρόμοια τεκμήρια

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ανά: Kawamura, A, κ.ά.
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ανά: Kawamura, A, κ.ά.
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ανά: Ng, S, κ.ά.
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ανά: Brewitz, L, κ.ά.
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ανά: Peng Liang
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ανά: Jose A. Viscarra, κ.ά.
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ανά: Rohit Chandwani, κ.ά.
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ανά: Thomas Burgold, κ.ά.
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ανά: Yang, J, κ.ά.
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