Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Show other versions (1)

Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...

書目詳細資料
Main Authors:	Thalhammer, A, Mecinović, J, Loenarz, C, Tumber, A, Rose, N, Heightman, T, Schofield, C
格式:	Journal article
語言:	English
出版:	2011

相似書籍

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.
由: Thalhammer, A, et al.
出版: (2011)

Zn-ejection for the selective inhibition of JMJD2 histone demethylases
由: Sekirnik, R, et al.
出版: (2012)

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
由: Sekirnik, R, et al.
出版: (2009)

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
由: Rose, N, et al.
出版: (2010)

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
由: Rose, N, et al.
出版: (2010)

Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.
由: Chang, K, et al.
出版: (2011)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
由: Kawamura, A, et al.
出版: (2010)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
由: Kawamura, A, et al.
出版: (2010)

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
由: Ng, S, et al.
出版: (2007)

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
由: Brewitz, L, et al.
出版: (2021)

5-substituted pyridine-2,4-dicarboxylate derivatives have potential for selective inhibition of human Jumonji-C domain-containing protein 5
由: Brewitz, L, et al.
出版: (2023)

Histone demethylase JmjD2A regulates neural crest specification.
由: Strobl-Mazzulla, P, et al.
出版: (2010)

The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
由: Jia Yang, et al.
出版: (2022-04-01)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
由: Rose, N, et al.
出版: (2008)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
由: Rose, N, et al.
出版: (2008)

Dioxygen binding in the active site of histone demethylase JMJD2A and the role of the protein environment
由: Cortopassi, W, et al.
出版: (2015)

Dioxygen binding in the active site of histone demethylase JMJD2A and the role of the protein environment
由: Cortopassi, W, et al.
出版: (2015)

Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
由: Lizcano Fernando, et al.
出版: (2011-01-01)

Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
由: Lizcano Fernando, et al.
出版: (2011-01-01)

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression
由: Panxia Wang, et al.
出版: (2020-09-01)

SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A
由: Ruicai Gu, et al.
出版: (2023-10-01)

The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy
由: Shuang Yu, et al.
出版: (2020-06-01)

The Histone Demethylase JMJD2A Modulates the Induction of Hypertrophy Markers in iPSC-Derived Cardiomyocytes
由: Wendy Rosales, et al.
出版: (2018-02-01)

The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and Is Associated With Blood Pressure
由: Kevin Mangum, et al.
出版: (2023-01-01)

A cocrystal of pyridine-2,4-dicarboxylic acid and serine
由: Peng Liang
出版: (2008-01-01)

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
由: Jose A. Viscarra, et al.
出版: (2020-02-01)

Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d
由: Rohit Chandwani, et al.
出版: (2023-05-01)

The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment.
由: Thomas Burgold, et al.
出版: (2008-08-01)

In vitro enzyme assays for JmjC-domain-containing lysine histone demethylases (JmjC-KDMs)
由: Tarhonskaya, H, et al.
出版: (2018)

SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication.
由: Wan-Shan Yang, et al.
出版: (2017-02-01)

Pyridine 2,4-Dicarboxylic Acid Suppresses Tomato Seedling Growth
由: Sotirios Fragkostefanakis, et al.
出版: (2018-01-01)

The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.
由: Yang, J, et al.
出版: (2010)

8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors
由: Bavetsias, V, et al.
出版: (2016)

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.
由: Hillringhaus, L, et al.
出版: (2011)

Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
由: Dezhi Chen, et al.
出版: (2024-04-01)

Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells
由: Chongyang Shen, et al.
出版: (2018-08-01)

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3.
由: Maureen M Sherry-Lynes, et al.
出版: (2017-01-01)

Advances and challenges in understanding histone demethylase biology
由: Nowak, R, et al.
出版: (2016)

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
由: Kader Salifou, et al.
出版: (2016-01-01)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
由: Chowdhury, R, et al.
出版: (2011)