Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...

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Autori principali: Thalhammer, A, Mecinović, J, Loenarz, C, Tumber, A, Rose, N, Heightman, T, Schofield, C
Natura: Journal article
Lingua:English
Pubblicazione: 2011