Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.
The memory dysfunction of Alzheimer disease has been associated with a cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert. This cholinergic component of Alzheimer disease can be modeled in the rat by ibotenic acid lesions of the cholinergic nucleus basa...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1985
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| _version_ | 1797050455097868288 |
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| author | Fine, A Dunnett, S Björklund, A Iversen, S |
| author_facet | Fine, A Dunnett, S Björklund, A Iversen, S |
| author_sort | Fine, A |
| collection | OXFORD |
| description | The memory dysfunction of Alzheimer disease has been associated with a cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert. This cholinergic component of Alzheimer disease can be modeled in the rat by ibotenic acid lesions of the cholinergic nucleus basalis magnocellularis. The memory impairment caused by such unilateral lesions, as reflected in passive avoidance behavior, is reversed by grafts into the deafferented neocortex of embryonic neurons of the cholinergic ventral forebrain, but not by grafts of noncholinergic hippocampal cells. |
| first_indexed | 2024-03-06T18:05:24Z |
| format | Journal article |
| id | oxford-uuid:0142c224-b361-41a0-8916-689e5064cdb4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:05:24Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:0142c224-b361-41a0-8916-689e5064cdb42022-03-26T08:33:57ZCholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0142c224-b361-41a0-8916-689e5064cdb4EnglishSymplectic Elements at Oxford1985Fine, ADunnett, SBjörklund, AIversen, SThe memory dysfunction of Alzheimer disease has been associated with a cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert. This cholinergic component of Alzheimer disease can be modeled in the rat by ibotenic acid lesions of the cholinergic nucleus basalis magnocellularis. The memory impairment caused by such unilateral lesions, as reflected in passive avoidance behavior, is reversed by grafts into the deafferented neocortex of embryonic neurons of the cholinergic ventral forebrain, but not by grafts of noncholinergic hippocampal cells. |
| spellingShingle | Fine, A Dunnett, S Björklund, A Iversen, S Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. |
| title | Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. |
| title_full | Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. |
| title_fullStr | Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. |
| title_full_unstemmed | Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. |
| title_short | Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. |
| title_sort | cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of alzheimer disease |
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