Monitoring fetal maturation-objectives, techniques and indices of autonomic function.
Monitoring the fetal behavior does not only have implications for acute care but also for identifying developmental disturbances that burden the entire later life. The concept, of 'fetal programming', also known as 'developmental origins of adult disease hypothesis', e.g. applies...
| Үндсэн зохиолчид: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Institute of Physics
2017
|
| _version_ | 1826256639500484608 |
|---|---|
| author | Hoyer, D Żebrowski, J Cysarz, D Gonçalves, H Pytlik, A Amorim-Costa, C Bernardes, J Ayres-de-Campos, D Witte, OW Schleußner, E Stroux, L Redman, C Georgieva, A Payne, S Clifford, G Signorini, MG Magenes, G Andreotti, F Malberg, H Zaunseder, S Lakhno, I Schneider, U |
| author_facet | Hoyer, D Żebrowski, J Cysarz, D Gonçalves, H Pytlik, A Amorim-Costa, C Bernardes, J Ayres-de-Campos, D Witte, OW Schleußner, E Stroux, L Redman, C Georgieva, A Payne, S Clifford, G Signorini, MG Magenes, G Andreotti, F Malberg, H Zaunseder, S Lakhno, I Schneider, U |
| author_sort | Hoyer, D |
| collection | OXFORD |
| description | Monitoring the fetal behavior does not only have implications for acute care but also for identifying developmental disturbances that burden the entire later life. The concept, of 'fetal programming', also known as 'developmental origins of adult disease hypothesis', e.g. applies for cardiovascular, metabolic, hyperkinetic, cognitive disorders. Since the autonomic nervous system is involved in all of those systems, cardiac autonomic control may provide relevant functional diagnostic and prognostic information. The fetal heart rate patterns (HRP) are one of the few functional signals in the prenatal period that relate to autonomic control and, therefore, is predestinated for its evaluation. The development of sensitive markers of fetal maturation and its disturbances requires the consideration of physiological fundamentals, recording technology and HRP parameters of autonomic control. Based on the ESGCO2016 special session on monitoring the fetal maturation we herein report the most recent results on: (i) functional fetal autonomic brain age score (fABAS), Recurrence Quantitative Analysis and Binary Symbolic Dynamics of complex HRP resolve specific maturation periods, (ii) magnetocardiography (MCG) based fABAS was validated for cardiotocography (CTG), (iii) 30 min recordings are sufficient for obtaining episodes of high variability, important for intrauterine growth restriction (IUGR) detection in handheld Doppler, (iv) novel parameters from PRSA to identify Intra IUGR fetuses, (v) evaluation of fetal electrocardiographic (ECG) recordings, (vi) correlation between maternal and fetal HRV is disturbed in pre-eclampsia. The reported novel developments significantly extend the possibilities for the established CTG methodology. Novel HRP indices improve the accuracy of assessment due to their more appropriate consideration of complex autonomic processes across the recording technologies (CTG, handheld Doppler, MCG, ECG). The ultimate objective is their dissemination into routine practice and studies of fetal developmental disturbances with implications for programming of adult diseases. |
| first_indexed | 2024-03-06T18:05:26Z |
| format | Journal article |
| id | oxford-uuid:0144c29b-dee4-45b6-941f-b572ef033d92 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:05:26Z |
| publishDate | 2017 |
| publisher | Institute of Physics |
| record_format | dspace |
| spelling | oxford-uuid:0144c29b-dee4-45b6-941f-b572ef033d922022-03-26T08:34:02ZMonitoring fetal maturation-objectives, techniques and indices of autonomic function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0144c29b-dee4-45b6-941f-b572ef033d92EnglishSymplectic Elements at OxfordInstitute of Physics2017Hoyer, DŻebrowski, JCysarz, DGonçalves, HPytlik, AAmorim-Costa, CBernardes, JAyres-de-Campos, DWitte, OWSchleußner, EStroux, LRedman, CGeorgieva, APayne, SClifford, GSignorini, MGMagenes, GAndreotti, FMalberg, HZaunseder, SLakhno, ISchneider, UMonitoring the fetal behavior does not only have implications for acute care but also for identifying developmental disturbances that burden the entire later life. The concept, of 'fetal programming', also known as 'developmental origins of adult disease hypothesis', e.g. applies for cardiovascular, metabolic, hyperkinetic, cognitive disorders. Since the autonomic nervous system is involved in all of those systems, cardiac autonomic control may provide relevant functional diagnostic and prognostic information. The fetal heart rate patterns (HRP) are one of the few functional signals in the prenatal period that relate to autonomic control and, therefore, is predestinated for its evaluation. The development of sensitive markers of fetal maturation and its disturbances requires the consideration of physiological fundamentals, recording technology and HRP parameters of autonomic control. Based on the ESGCO2016 special session on monitoring the fetal maturation we herein report the most recent results on: (i) functional fetal autonomic brain age score (fABAS), Recurrence Quantitative Analysis and Binary Symbolic Dynamics of complex HRP resolve specific maturation periods, (ii) magnetocardiography (MCG) based fABAS was validated for cardiotocography (CTG), (iii) 30 min recordings are sufficient for obtaining episodes of high variability, important for intrauterine growth restriction (IUGR) detection in handheld Doppler, (iv) novel parameters from PRSA to identify Intra IUGR fetuses, (v) evaluation of fetal electrocardiographic (ECG) recordings, (vi) correlation between maternal and fetal HRV is disturbed in pre-eclampsia. The reported novel developments significantly extend the possibilities for the established CTG methodology. Novel HRP indices improve the accuracy of assessment due to their more appropriate consideration of complex autonomic processes across the recording technologies (CTG, handheld Doppler, MCG, ECG). The ultimate objective is their dissemination into routine practice and studies of fetal developmental disturbances with implications for programming of adult diseases. |
| spellingShingle | Hoyer, D Żebrowski, J Cysarz, D Gonçalves, H Pytlik, A Amorim-Costa, C Bernardes, J Ayres-de-Campos, D Witte, OW Schleußner, E Stroux, L Redman, C Georgieva, A Payne, S Clifford, G Signorini, MG Magenes, G Andreotti, F Malberg, H Zaunseder, S Lakhno, I Schneider, U Monitoring fetal maturation-objectives, techniques and indices of autonomic function. |
| title | Monitoring fetal maturation-objectives, techniques and indices of autonomic function. |
| title_full | Monitoring fetal maturation-objectives, techniques and indices of autonomic function. |
| title_fullStr | Monitoring fetal maturation-objectives, techniques and indices of autonomic function. |
| title_full_unstemmed | Monitoring fetal maturation-objectives, techniques and indices of autonomic function. |
| title_short | Monitoring fetal maturation-objectives, techniques and indices of autonomic function. |
| title_sort | monitoring fetal maturation objectives techniques and indices of autonomic function |
| work_keys_str_mv | AT hoyerd monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT zebrowskij monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT cysarzd monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT goncalvesh monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT pytlika monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT amorimcostac monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT bernardesj monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT ayresdecamposd monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT witteow monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT schleußnere monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT strouxl monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT redmanc monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT georgievaa monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT paynes monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT cliffordg monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT signorinimg monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT magenesg monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT andreottif monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT malbergh monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT zaunseders monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT lakhnoi monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction AT schneideru monitoringfetalmaturationobjectivestechniquesandindicesofautonomicfunction |