Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort
Concerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (IQR) age at recruitment of 72.6 (66.6-77.8) yr, of whom 109 had moderate or major surgery during a media...
| Main Authors: | , , , , |
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| Format: | Journal article |
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Wiley
2016
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| _version_ | 1797050473212018688 |
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| author | Patel, D Lunn, A Smith, A Lehmann, D Dorrington, K |
| author_facet | Patel, D Lunn, A Smith, A Lehmann, D Dorrington, K |
| author_sort | Patel, D |
| collection | OXFORD |
| description | Concerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (IQR) age at recruitment of 72.6 (66.6-77.8) yr, of whom 109 had moderate or major surgery during a median (IQR) follow-up of 4.1 (2.0-7.6) yr. Cognitive decline was more rapid in people who: on recruitment were older, p = 0.0003, male, p = 0.027, had worse cognition, p< 0.0001, or carried the ε4 allele of apoliprotein E (APOEε4), p = 0.008; and after an operation if cognitive impairment was already diagnosed, p = 0.0001. Cognitive decline appears to accelerate after surgery in elderly patients diagnosed with cognitive impairment, but not other elderly patients. |
| first_indexed | 2024-03-06T18:05:40Z |
| format | Journal article |
| id | oxford-uuid:015b0f37-7029-4030-b3f1-f6f2e5a0ee84 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:05:40Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:015b0f37-7029-4030-b3f1-f6f2e5a0ee842022-03-26T08:34:29ZCognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:015b0f37-7029-4030-b3f1-f6f2e5a0ee84Symplectic Elements at OxfordWiley2016Patel, DLunn, ASmith, ALehmann, DDorrington, KConcerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (IQR) age at recruitment of 72.6 (66.6-77.8) yr, of whom 109 had moderate or major surgery during a median (IQR) follow-up of 4.1 (2.0-7.6) yr. Cognitive decline was more rapid in people who: on recruitment were older, p = 0.0003, male, p = 0.027, had worse cognition, p< 0.0001, or carried the ε4 allele of apoliprotein E (APOEε4), p = 0.008; and after an operation if cognitive impairment was already diagnosed, p = 0.0001. Cognitive decline appears to accelerate after surgery in elderly patients diagnosed with cognitive impairment, but not other elderly patients. |
| spellingShingle | Patel, D Lunn, A Smith, A Lehmann, D Dorrington, K Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort |
| title | Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort |
| title_full | Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort |
| title_fullStr | Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort |
| title_full_unstemmed | Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort |
| title_short | Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort |
| title_sort | cognitive decline in the elderly after surgery and anaesthesia results from the oxford project to investigate memory and ageing optima cohort |
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