Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management
Osteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligam...
| Những tác giả chính: | , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
Springer Nature
2018
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| _version_ | 1826256691362004992 |
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| author | Marshall, M Watt, FE Vincent, TL Dziedzic, K |
| author_facet | Marshall, M Watt, FE Vincent, TL Dziedzic, K |
| author_sort | Marshall, M |
| collection | OXFORD |
| description | Osteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This Review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in the disease. |
| first_indexed | 2024-03-06T18:06:15Z |
| format | Journal article |
| id | oxford-uuid:01838116-75d9-41a8-b3da-b6879861ddc8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:06:15Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:01838116-75d9-41a8-b3da-b6879861ddc82022-03-26T08:35:28ZHand osteoarthritis: clinical phenotypes, molecular mechanisms and disease managementJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:01838116-75d9-41a8-b3da-b6879861ddc8EnglishSymplectic Elements at OxfordSpringer Nature2018Marshall, MWatt, FEVincent, TLDziedzic, KOsteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This Review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in the disease. |
| spellingShingle | Marshall, M Watt, FE Vincent, TL Dziedzic, K Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management |
| title | Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management |
| title_full | Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management |
| title_fullStr | Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management |
| title_full_unstemmed | Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management |
| title_short | Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management |
| title_sort | hand osteoarthritis clinical phenotypes molecular mechanisms and disease management |
| work_keys_str_mv | AT marshallm handosteoarthritisclinicalphenotypesmolecularmechanismsanddiseasemanagement AT wattfe handosteoarthritisclinicalphenotypesmolecularmechanismsanddiseasemanagement AT vincenttl handosteoarthritisclinicalphenotypesmolecularmechanismsanddiseasemanagement AT dziedzick handosteoarthritisclinicalphenotypesmolecularmechanismsanddiseasemanagement |