A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta 67[E11] Val-Met->Asp).

A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta 67[E11] Val-Met->Asp).

The first reported case of congenital Heinz body hemolytic anemia was subsequently shown to be caused by an unstable hemoglobin, Hb Bristol [beta 67(E11) Val-Asp]. This has become one of the classic models of an unstable hemoglobin, the hydrophilic aspartate disrupting the hydrophobic heme pocket. W...

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Bibliographic Details
Main Authors: Rees, D, Rochette, J, Schofield, C, Green, B, Morris, M, Parker, N, Sasaki, H, Tanaka, A, Ohba, Y, Clegg, J
Format: Journal article
Language:English
Published: 1996

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