Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.

BACKGROUND: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in mismatch repair genes and predisposes individuals to cancers of the colon and other specific sites. On theoretical grounds, it is expected that patients with HNPCC also develop more colorec...

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Bibliographic Details
Main Authors:	Beck, N, Tomlinson, I, Homfray, T, Frayling, I, Hodgson, S, Bodmer, W
Format:	Journal article
Language:	English
Published:	1997

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