Dynamic protein methylation in chromatin biology.
Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Rec...
Main Authors: | , , , |
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Format: | Journal article |
Language: | English |
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2009
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_version_ | 1797050561023967232 |
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author | Ng, S Yue, W Oppermann, U Klose, R |
author_facet | Ng, S Yue, W Oppermann, U Klose, R |
author_sort | Ng, S |
collection | OXFORD |
description | Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals. |
first_indexed | 2024-03-06T18:06:58Z |
format | Journal article |
id | oxford-uuid:01bebc98-a553-49bc-a930-1280072931db |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T18:06:58Z |
publishDate | 2009 |
record_format | dspace |
spelling | oxford-uuid:01bebc98-a553-49bc-a930-1280072931db2022-03-26T08:36:46ZDynamic protein methylation in chromatin biology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:01bebc98-a553-49bc-a930-1280072931dbEnglishSymplectic Elements at Oxford2009Ng, SYue, WOppermann, UKlose, RPost-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals. |
spellingShingle | Ng, S Yue, W Oppermann, U Klose, R Dynamic protein methylation in chromatin biology. |
title | Dynamic protein methylation in chromatin biology. |
title_full | Dynamic protein methylation in chromatin biology. |
title_fullStr | Dynamic protein methylation in chromatin biology. |
title_full_unstemmed | Dynamic protein methylation in chromatin biology. |
title_short | Dynamic protein methylation in chromatin biology. |
title_sort | dynamic protein methylation in chromatin biology |
work_keys_str_mv | AT ngs dynamicproteinmethylationinchromatinbiology AT yuew dynamicproteinmethylationinchromatinbiology AT oppermannu dynamicproteinmethylationinchromatinbiology AT kloser dynamicproteinmethylationinchromatinbiology |