Extracellular vesicles: biology and emerging therapeutic opportunities.
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathop...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1826256744666365952 |
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| author | Andaloussi, S Mäger, I Breakefield, X Wood, M |
| author_facet | Andaloussi, S Mäger, I Breakefield, X Wood, M |
| author_sort | Andaloussi, S |
| collection | OXFORD |
| description | Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges. |
| first_indexed | 2024-03-06T18:07:07Z |
| format | Journal article |
| id | oxford-uuid:01cc65ee-852d-4456-99c7-b3f4fba5cd87 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:07:07Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:01cc65ee-852d-4456-99c7-b3f4fba5cd872022-03-26T08:36:56ZExtracellular vesicles: biology and emerging therapeutic opportunities.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:01cc65ee-852d-4456-99c7-b3f4fba5cd87EnglishSymplectic Elements at Oxford2013Andaloussi, SMäger, IBreakefield, XWood, MWithin the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges. |
| spellingShingle | Andaloussi, S Mäger, I Breakefield, X Wood, M Extracellular vesicles: biology and emerging therapeutic opportunities. |
| title | Extracellular vesicles: biology and emerging therapeutic opportunities. |
| title_full | Extracellular vesicles: biology and emerging therapeutic opportunities. |
| title_fullStr | Extracellular vesicles: biology and emerging therapeutic opportunities. |
| title_full_unstemmed | Extracellular vesicles: biology and emerging therapeutic opportunities. |
| title_short | Extracellular vesicles: biology and emerging therapeutic opportunities. |
| title_sort | extracellular vesicles biology and emerging therapeutic opportunities |
| work_keys_str_mv | AT andaloussis extracellularvesiclesbiologyandemergingtherapeuticopportunities AT mageri extracellularvesiclesbiologyandemergingtherapeuticopportunities AT breakefieldx extracellularvesiclesbiologyandemergingtherapeuticopportunities AT woodm extracellularvesiclesbiologyandemergingtherapeuticopportunities |