Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.

Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.

We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplog...

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Bibliographic Details
Main Authors: Paracchini, S, Stuppia, L, Gatta, V, Palka, G, Moro, E, Foresta, C, Mengua, L, Oliva, R, Ballescà, J, Kremer, J, van Golde, R, Tuerlings, J, Hargreave, T, Ross, A, Cooke, H, Huellen, K, Vogt, P, Tyler-Smith, C
Format: Journal article
Language:English
Published: 2000
Description
Summary:We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplogroup frequencies were compared between 3 microdeletion classes and the non-deleted infertile males. Deletions arise on many different haplotypic backgrounds. No statistically significant differences in frequency were seen, although the small number of AZFa deletions lay predominantly on one branch of the Y haplotype tree.

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