The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

Homozygosity for the G allele of rs6983267 at 8q24 increases colorectal cancer (CRC) risk approximately 1.5 fold. We report here that the risk allele G shows copy number increase during CRC development. Our computer algorithm, Enhancer Element Locator (EEL), identified an enhancer element that conta...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Tuupanen, S, Turunen, M, Lehtonen, R, Hallikas, O, Vanharanta, S, Kivioja, T, Björklund, M, Wei, G, Yan, J, Niittymäki, I, Mecklin, J, Järvinen, H, Ristimäki, A, Di-Bernardo, M, East, P, Carvajal-Carmona, L, Houlston, R, Tomlinson, I, Palin, K, Ukkonen, E, Karhu, A, Taipale, J, Aaltonen, L
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2009

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