The impact of malaria parasites on dendritic cell–T cell interaction
Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against disease, this requires years of persistent exposure...
| Príomhchruthaitheoirí: | , , , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Frontiers Media
2020
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| _version_ | 1826256754394005504 |
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| author | Osii, RS Otto, TD Garside, P Ndungu, FM Brewer, JM |
| author_facet | Osii, RS Otto, TD Garside, P Ndungu, FM Brewer, JM |
| author_sort | Osii, RS |
| collection | OXFORD |
| description | Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against disease, this requires years of persistent exposure and is not associated with protection against infection. Repeat infections occur due to the parasite's ability to disrupt or evade the host immune responses. However, despite many years of study, the mechanisms of this disruption remain unclear. Previous studies have demonstrated a parasite-induced failure in dendritic cell (DCs) function affecting the generation of helper T cell responses. These T cells fail to help B cell responses, reducing the production of antibodies that are necessary to control malaria infection. This review focuses on our current understanding of the effect of Plasmodium parasite on DC function, DC-T cell interaction, and T cell activation. A better understanding of how parasites disrupt DC-T cell interactions will lead to new targets and approaches to reinstate adaptive immune responses and enhance parasite immunity. |
| first_indexed | 2024-03-06T18:07:16Z |
| format | Journal article |
| id | oxford-uuid:01dabc78-cd8c-4361-a7e6-032e27eae40b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:07:16Z |
| publishDate | 2020 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:01dabc78-cd8c-4361-a7e6-032e27eae40b2022-03-26T08:37:13ZThe impact of malaria parasites on dendritic cell–T cell interactionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:01dabc78-cd8c-4361-a7e6-032e27eae40bEnglishSymplectic ElementsFrontiers Media 2020Osii, RSOtto, TDGarside, PNdungu, FMBrewer, JMMalaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against disease, this requires years of persistent exposure and is not associated with protection against infection. Repeat infections occur due to the parasite's ability to disrupt or evade the host immune responses. However, despite many years of study, the mechanisms of this disruption remain unclear. Previous studies have demonstrated a parasite-induced failure in dendritic cell (DCs) function affecting the generation of helper T cell responses. These T cells fail to help B cell responses, reducing the production of antibodies that are necessary to control malaria infection. This review focuses on our current understanding of the effect of Plasmodium parasite on DC function, DC-T cell interaction, and T cell activation. A better understanding of how parasites disrupt DC-T cell interactions will lead to new targets and approaches to reinstate adaptive immune responses and enhance parasite immunity. |
| spellingShingle | Osii, RS Otto, TD Garside, P Ndungu, FM Brewer, JM The impact of malaria parasites on dendritic cell–T cell interaction |
| title | The impact of malaria parasites on dendritic cell–T cell interaction |
| title_full | The impact of malaria parasites on dendritic cell–T cell interaction |
| title_fullStr | The impact of malaria parasites on dendritic cell–T cell interaction |
| title_full_unstemmed | The impact of malaria parasites on dendritic cell–T cell interaction |
| title_short | The impact of malaria parasites on dendritic cell–T cell interaction |
| title_sort | impact of malaria parasites on dendritic cell t cell interaction |
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