A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.
Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1797050583433084928 |
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| author | Morahan, G Boutlis, C Huang, D Pain, A Saunders, JR Hobbs, MR Granger, D Weinberg, J Peshu, N Mwaikambo, E Marsh, K Roberts, D Anstey, N |
| author_facet | Morahan, G Boutlis, C Huang, D Pain, A Saunders, JR Hobbs, MR Granger, D Weinberg, J Peshu, N Mwaikambo, E Marsh, K Roberts, D Anstey, N |
| author_sort | Morahan, G |
| collection | OXFORD |
| description | Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population. |
| first_indexed | 2024-03-06T18:07:18Z |
| format | Journal article |
| id | oxford-uuid:01dd3440-11a4-4977-b0a7-c669b3e9ad60 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:07:18Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:01dd3440-11a4-4977-b0a7-c669b3e9ad602022-03-26T08:37:19ZA promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:01dd3440-11a4-4977-b0a7-c669b3e9ad60EnglishSymplectic Elements at Oxford2002Morahan, GBoutlis, CHuang, DPain, ASaunders, JRHobbs, MRGranger, DWeinberg, JPeshu, NMwaikambo, EMarsh, KRoberts, DAnstey, NInterleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population. |
| spellingShingle | Morahan, G Boutlis, C Huang, D Pain, A Saunders, JR Hobbs, MR Granger, D Weinberg, J Peshu, N Mwaikambo, E Marsh, K Roberts, D Anstey, N A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. |
| title | A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. |
| title_full | A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. |
| title_fullStr | A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. |
| title_full_unstemmed | A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. |
| title_short | A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. |
| title_sort | promoter polymorphism in the gene encoding interleukin 12 p40 il12b is associated with mortality from cerebral malaria and with reduced nitric oxide production |
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