The Genotype-Tissue Expression (GTEx) project.
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1797050617423724544 |
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| author | GTEx Consortium |
| author_facet | GTEx Consortium |
| author_sort | GTEx Consortium |
| collection | OXFORD |
| description | Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues. |
| first_indexed | 2024-03-06T18:07:49Z |
| format | Journal article |
| id | oxford-uuid:0203e0cd-52b9-49d2-9f2d-17283f650831 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:07:49Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:0203e0cd-52b9-49d2-9f2d-17283f6508312022-03-26T08:38:11ZThe Genotype-Tissue Expression (GTEx) project.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0203e0cd-52b9-49d2-9f2d-17283f650831EnglishSymplectic Elements at Oxford2013GTEx ConsortiumGenome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues. |
| spellingShingle | GTEx Consortium The Genotype-Tissue Expression (GTEx) project. |
| title | The Genotype-Tissue Expression (GTEx) project. |
| title_full | The Genotype-Tissue Expression (GTEx) project. |
| title_fullStr | The Genotype-Tissue Expression (GTEx) project. |
| title_full_unstemmed | The Genotype-Tissue Expression (GTEx) project. |
| title_short | The Genotype-Tissue Expression (GTEx) project. |
| title_sort | genotype tissue expression gtex project |
| work_keys_str_mv | AT gtexconsortium thegenotypetissueexpressiongtexproject AT gtexconsortium genotypetissueexpressiongtexproject |