Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study
Influenza epidemiology differs substantially in tropical and temperate zones, but estimates of seasonal influenza mortality in developing countries in the tropics are lacking. We aimed to quantify mortality due to seasonal influenza in Thailand, a tropical middle-income country. Time series of polym...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2015
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| _version_ | 1797050629434114048 |
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| author | Cooper, B Kotirum, S Kulpeng, W Praditsitthikorn, N Chittaganpitch, M Limmathurotsakul, D Day, N Coker, R Teerawattananon, Y Meeyai, A |
| author_facet | Cooper, B Kotirum, S Kulpeng, W Praditsitthikorn, N Chittaganpitch, M Limmathurotsakul, D Day, N Coker, R Teerawattananon, Y Meeyai, A |
| author_sort | Cooper, B |
| collection | OXFORD |
| description | Influenza epidemiology differs substantially in tropical and temperate zones, but estimates of seasonal influenza mortality in developing countries in the tropics are lacking. We aimed to quantify mortality due to seasonal influenza in Thailand, a tropical middle-income country. Time series of polymerase chain reaction-confirmed influenza infections between 2005 and 2009 were constructed from a sentinel surveillance network. These were combined with influenza-like illness data to derive measures of influenza activity and relationships to mortality by using a Bayesian regression framework. We estimated 6.1 (95% credible interval: 0.5, 12.4) annual deaths per 100,000 population attributable to influenza A and B, predominantly in those aged ≥60 years, with the largest contribution from influenza A(H1N1) in 3 out of 4 years. For A(H3N2), the relationship between influenza activity and mortality varied over time. Influenza was associated with increases in deaths classified as resulting from respiratory disease (posterior probability of positive association, 99.8%), cancer (98.6%), renal disease (98.0%), and liver disease (99.2%). No association with circulatory disease mortality was found. Seasonal influenza infections are associated with substantial mortality in Thailand, but evidence for the strong relationship between influenza activity and circulatory disease mortality reported in temperate countries is lacking. |
| first_indexed | 2024-03-06T18:08:00Z |
| format | Journal article |
| id | oxford-uuid:02160590-f967-4dbe-88dc-7ace8b3a8401 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:08:00Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:02160590-f967-4dbe-88dc-7ace8b3a84012022-03-26T08:38:36ZMortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02160590-f967-4dbe-88dc-7ace8b3a8401EnglishSymplectic Elements at OxfordOxford University Press2015Cooper, BKotirum, SKulpeng, WPraditsitthikorn, NChittaganpitch, MLimmathurotsakul, DDay, NCoker, RTeerawattananon, YMeeyai, AInfluenza epidemiology differs substantially in tropical and temperate zones, but estimates of seasonal influenza mortality in developing countries in the tropics are lacking. We aimed to quantify mortality due to seasonal influenza in Thailand, a tropical middle-income country. Time series of polymerase chain reaction-confirmed influenza infections between 2005 and 2009 were constructed from a sentinel surveillance network. These were combined with influenza-like illness data to derive measures of influenza activity and relationships to mortality by using a Bayesian regression framework. We estimated 6.1 (95% credible interval: 0.5, 12.4) annual deaths per 100,000 population attributable to influenza A and B, predominantly in those aged ≥60 years, with the largest contribution from influenza A(H1N1) in 3 out of 4 years. For A(H3N2), the relationship between influenza activity and mortality varied over time. Influenza was associated with increases in deaths classified as resulting from respiratory disease (posterior probability of positive association, 99.8%), cancer (98.6%), renal disease (98.0%), and liver disease (99.2%). No association with circulatory disease mortality was found. Seasonal influenza infections are associated with substantial mortality in Thailand, but evidence for the strong relationship between influenza activity and circulatory disease mortality reported in temperate countries is lacking. |
| spellingShingle | Cooper, B Kotirum, S Kulpeng, W Praditsitthikorn, N Chittaganpitch, M Limmathurotsakul, D Day, N Coker, R Teerawattananon, Y Meeyai, A Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study |
| title | Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study |
| title_full | Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study |
| title_fullStr | Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study |
| title_full_unstemmed | Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study |
| title_short | Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study |
| title_sort | mortality attributable to seasonal influenza a and b infections in thailand 2005 2009 a longitudinal study |
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