PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are therefore key drug targets1. Although detailed structural information is available for GPCRs, the effects of lipids on the receptors, and on downstream coupling of GPCRs to G proteins are largely unknown. Here w...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Yen, H, Hoi, K, Liko, I, Hedger, G, Horrell, M, Song, W, Wu, D, Heine, P, Warne, T, Lee, Y, Carpenter, B, Plückthun, A, Tate, C, Sansom, M, Robinson, C
Fformat:	Journal article
Cyhoeddwyd:	Springer Nature 2018

Eitemau Tebyg

PIP2 stabilises active states of GPCRs and enhances the selectivity
gan: Yen, H, et al.
Cyhoeddwyd: (2018)

The possible role of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 at the leading and trailing edges of the breast cancer cell line
gan: Dhurgam AL-Fahad
Cyhoeddwyd: (2021-01-01)

Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.
gan: Karen E Anderson, et al.
Cyhoeddwyd: (2013-01-01)

A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.
gan: Halstead, JR, et al.
Cyhoeddwyd: (2006)

Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.
gan: Ford, MG, et al.
Cyhoeddwyd: (2001)

Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy
gan: Cheng-Wei Hsieh, et al.
Cyhoeddwyd: (2019-02-01)

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation.
gan: Diego Sbrissa, et al.
Cyhoeddwyd: (2018-01-01)

The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma.
gan: Trupti Joshi, et al.
Cyhoeddwyd: (2009-01-01)

PtdIns (3,4,5) P3 recruitment of Myo10 is essential for axon development.
gan: Huali Yu, et al.
Cyhoeddwyd: (2012-01-01)

Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.
gan: Jones, DR, et al.
Cyhoeddwyd: (2006)

Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
gan: Oscar Vivas, et al.
Cyhoeddwyd: (2019-05-01)

The PtdIns3P phosphatase MtMP promotes symbiotic nitrogen fixation via mitophagy in Medicago truncatula
gan: Qixia Xue, et al.
Cyhoeddwyd: (2023-10-01)

Variable regions of PI4P 5-kinases direct PtdIns(4,5)P2 towards alternative regulatory functions in tobacco pollen tubes
gan: Irene eStenzel, et al.
Cyhoeddwyd: (2012-01-01)

Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.
gan: Pinal, N, et al.
Cyhoeddwyd: (2006)

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.
gan: Michael A Kennedy, et al.
Cyhoeddwyd: (2014-01-01)

LL5 directs the translocation of Filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2
gan: Takabayashi, Tetsuji, et al.
Cyhoeddwyd: (2010)

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes
gan: James P Zewe, et al.
Cyhoeddwyd: (2018-02-01)

Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2.
gan: Kiyomi Nigorikawa, et al.
Cyhoeddwyd: (2015-01-01)

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function
gan: Tom N. Durrant, et al.
Cyhoeddwyd: (2017-06-01)

Control of the signaling role of PtdIns(4)P at the plasma membrane through H2O2-dependent inactivation of synaptojanin 2 during endocytosis
gan: Su In Jo, et al.
Cyhoeddwyd: (2024-05-01)

G protein-coupled receptor lipid interactions: Insights from molecular dynamics simulations
gan: Hedger, G, et al.
Cyhoeddwyd: (2017)

Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.
gan: van den Bout, I, et al.
Cyhoeddwyd: (2013)

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach
gan: Hervé Guillou, et al.
Cyhoeddwyd: (2007-03-01)

PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium
gan: Ángel Pérez-Lara, et al.
Cyhoeddwyd: (2016-10-01)

Z życia PTD
Cyhoeddwyd: (2023-05-01)

Z ŻYCIA PTD
Cyhoeddwyd: (2017-07-01)

Z ŻYCIA PTD
gan: Magdalena Cichocka, et al.
Cyhoeddwyd: (2017-04-01)

Z życia PTD
Cyhoeddwyd: (2017-11-01)

Z życia PTD
Cyhoeddwyd: (2019-12-01)

Z życia PTD
Cyhoeddwyd: (2021-06-01)

Z życia PTD
Cyhoeddwyd: (2017-12-01)

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.
gan: Clark, J, et al.
Cyhoeddwyd: (2011)

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry
gan: Clark, J, et al.
Cyhoeddwyd: (2011)

G Protein-Coupled Receptors (GPCRs) in Alzheimer’s Disease: A Focus on BACE1 Related GPCRs
gan: Juan eZhao, et al.
Cyhoeddwyd: (2016-03-01)

Mini-G proteins: Novel tools for studying GPCRs in their active conformation.
gan: Rony Nehmé, et al.
Cyhoeddwyd: (2017-01-01)

The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
gan: Tomasz Boczek, et al.
Cyhoeddwyd: (2021-05-01)

Super-complexes of adhesion GPCRs and neural guidance receptors
gan: Seiradake, E, et al.
Cyhoeddwyd: (2016)

A Vaccinia-based system for directed evolution of GPCRs in mammalian cells
gan: Christoph Klenk, et al.
Cyhoeddwyd: (2023-03-01)

Rules and mechanisms governing G protein coupling selectivity of GPCRs
gan: Ikuo Masuho, et al.
Cyhoeddwyd: (2023-10-01)

Constitutive G protein coupling profiles of understudied orphan GPCRs.
gan: Sumin Lu, et al.
Cyhoeddwyd: (2021-01-01)