PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are therefore key drug targets1. Although detailed structural information is available for GPCRs, the effects of lipids on the receptors, and on downstream coupling of GPCRs to G proteins are largely unknown. Here w...

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Hlavní autoři: Yen, H, Hoi, K, Liko, I, Hedger, G, Horrell, M, Song, W, Wu, D, Heine, P, Warne, T, Lee, Y, Carpenter, B, Plückthun, A, Tate, C, Sansom, M, Robinson, C
Médium: Journal article
Vydáno: Springer Nature 2018

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