In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors
<p>Zinc ion dependent β-lactamases (MBLs) catalyze the hydrolysis of almost all β-lactam antibiotics and resist the action of clinically available β-lactamase inhibitors. We report how application of <i>in silico</i> fragment-based molecular design employing thiol-mediated metal a...
| Egile Nagusiak: | , , , , , , , , , , , , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
American Chemical Society
2017
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