In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors

In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors

<p>Zinc ion dependent β-lactamases (MBLs) catalyze the hydrolysis of almost all β-lactam antibiotics and resist the action of clinically available β-lactamase inhibitors. We report how application of <i>in silico</i> fragment-based molecular design employing thiol-mediated metal a...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cain, R, Brem, J, Zollman, D, McDonough, M, Johnson, R, Spencer, J, Makena, A, Abboud, M, Cahill, S, Lee, S, McHugh, P, Schofield, C, Fishwick, C
التنسيق: Journal article
اللغة:English
منشور في: American Chemical Society 2017

مواد مشابهة

مواد مشابهة