A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F.
An entirely substrate-controlled total synthesis of three members of the thapsigargin family (e.g. trilobolide) is achieved starting from (S)-carvone. The synthesis is linear in nature but is achieved in high yield (> 90% per step). The route permits late-stage divergence, providing access to...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1826256873773334528 |
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| author | Oliver, S Högenauer, K Simic, O Antonello, A Smith, M Ley, S |
| author_facet | Oliver, S Högenauer, K Simic, O Antonello, A Smith, M Ley, S |
| author_sort | Oliver, S |
| collection | OXFORD |
| description | An entirely substrate-controlled total synthesis of three members of the thapsigargin family (e.g. trilobolide) is achieved starting from (S)-carvone. The synthesis is linear in nature but is achieved in high yield (> 90% per step). The route permits late-stage divergence, providing access to a range of natural products and structural analogues. |
| first_indexed | 2024-03-06T18:09:11Z |
| format | Journal article |
| id | oxford-uuid:026a834b-dc4b-4b9b-a111-88058b4ebaaa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:09:11Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:026a834b-dc4b-4b9b-a111-88058b4ebaaa2022-03-26T08:40:36ZA route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:026a834b-dc4b-4b9b-a111-88058b4ebaaaEnglishSymplectic Elements at Oxford2003Oliver, SHögenauer, KSimic, OAntonello, ASmith, MLey, SAn entirely substrate-controlled total synthesis of three members of the thapsigargin family (e.g. trilobolide) is achieved starting from (S)-carvone. The synthesis is linear in nature but is achieved in high yield (> 90% per step). The route permits late-stage divergence, providing access to a range of natural products and structural analogues. |
| spellingShingle | Oliver, S Högenauer, K Simic, O Antonello, A Smith, M Ley, S A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. |
| title | A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. |
| title_full | A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. |
| title_fullStr | A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. |
| title_full_unstemmed | A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. |
| title_short | A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. |
| title_sort | route to the thapsigargins from s carvone providing a substrate controlled total synthesis of trilobolide nortrilobolide and thapsivillosin f |
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