Supramolecular cylinders target bulge structures in the 5′ UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication

Supramolecular cylinders target bulge structures in the 5′ UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication

The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti-virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D m...

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Bibliografische gegevens
Hoofdauteurs: Melidis, L, Hill, HJ, Coltman, NJ, Davies, SP, Winczura, K, Chauhan, T, Craig, JS, Garai, A, Hooper, CAJ, Egan, RT, McKeating, JA, Hodges, NJ, Stamataki, Z, Grzechnik, P, Hannon, MJ
Formaat: Journal article
Taal:English
Gepubliceerd in: Wiley 2021

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