The age-specific force of natural selection and biodemographic walls of death
<p style="text-align:justify;"> W. D. Hamilton’s celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton’s setting the full...
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| Format: | Journal article |
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National Academy of Sciences
2013
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| _version_ | 1826256936314601472 |
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| author | Wachter, KW Evans, SN Steinsaltz, DR |
| author_facet | Wachter, KW Evans, SN Steinsaltz, DR |
| author_sort | Wachter, KW |
| collection | OXFORD |
| description | <p style="text-align:justify;"> W. D. Hamilton’s celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton’s setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane’s principle for genetic load has an exact but unfamiliar generalization. </p> |
| first_indexed | 2024-03-06T18:10:11Z |
| format | Journal article |
| id | oxford-uuid:02c05a3a-6276-44be-bedb-6c45cb2bb1a7 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:10:11Z |
| publishDate | 2013 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:02c05a3a-6276-44be-bedb-6c45cb2bb1a72022-03-26T08:42:25ZThe age-specific force of natural selection and biodemographic walls of deathJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02c05a3a-6276-44be-bedb-6c45cb2bb1a7Symplectic Elements at OxfordNational Academy of Sciences2013Wachter, KWEvans, SNSteinsaltz, DR <p style="text-align:justify;"> W. D. Hamilton’s celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton’s setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane’s principle for genetic load has an exact but unfamiliar generalization. </p> |
| spellingShingle | Wachter, KW Evans, SN Steinsaltz, DR The age-specific force of natural selection and biodemographic walls of death |
| title | The age-specific force of natural selection and biodemographic walls of death |
| title_full | The age-specific force of natural selection and biodemographic walls of death |
| title_fullStr | The age-specific force of natural selection and biodemographic walls of death |
| title_full_unstemmed | The age-specific force of natural selection and biodemographic walls of death |
| title_short | The age-specific force of natural selection and biodemographic walls of death |
| title_sort | age specific force of natural selection and biodemographic walls of death |
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