The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study.
OBJECTIVE: To investigate the relationship between bullous pemphigoid (BP) and neurologic disease. DESIGN: Case-control study. SETTING: Tertiary care center for immunobullous diseases and skin tumor clinics at a university hospital in Oxford, England. PARTICIPANTS: Ninety consecutive patients with...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826256950362374144 |
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| author | Taghipour, K Chi, C Vincent, A Groves, R Venning, V Wojnarowska, F |
| author_facet | Taghipour, K Chi, C Vincent, A Groves, R Venning, V Wojnarowska, F |
| author_sort | Taghipour, K |
| collection | OXFORD |
| description | OBJECTIVE: To investigate the relationship between bullous pemphigoid (BP) and neurologic disease. DESIGN: Case-control study. SETTING: Tertiary care center for immunobullous diseases and skin tumor clinics at a university hospital in Oxford, England. PARTICIPANTS: Ninety consecutive patients with BP and 141 controls. MAIN OUTCOME MEASURES: Age-adjusted prevalence of neurologic disease in patients and controls. Time interval between the diagnosis of neurologic disease and BP and type of associated neurologic disease. RESULTS: At least 1 neurologic diagnosis was present in 42 patients (46%) compared with 16 controls (11%). Patients had significantly increased odds for neurologic diseases regardless of age and sex (crude odds ratio [OR], 6.8; 95% confidence interval [CI], 3.5-13.3; adjusted OR, 6.2; 95% CI, 3.1-12.4). Four major neurologic diagnoses were observed (cerebrovascular disease, dementia, Parkinson disease, and epilepsy), with statistical significance for cerebrovascular disease and dementia (crude OR for cerebrovascular disease, 6.3; 95% CI, 2.8-14.2; adjusted OR, 6.0; 95% CI, 2.6-13.6; crude OR for dementia, 10.7; 95% CI, 2.3-49.0; adjusted OR, 7.9; 95% CI, 1.7-37.3). When accurate data on time of onset of neurologic disease were present (36 of 42 patients [85%]), BP followed neurologic disease in most patients (26 of 36 patients [72%]), with a median interval of 5.5 years. CONCLUSION: Bullous pemphigoid is significantly associated with cerebrovascular disease and dementia. |
| first_indexed | 2024-03-06T18:10:24Z |
| format | Journal article |
| id | oxford-uuid:02d11e29-6f80-4174-824b-9f0bdf0dc4f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:10:24Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:02d11e29-6f80-4174-824b-9f0bdf0dc4f42022-03-26T08:42:50ZThe association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02d11e29-6f80-4174-824b-9f0bdf0dc4f4EnglishSymplectic Elements at Oxford2010Taghipour, KChi, CVincent, AGroves, RVenning, VWojnarowska, F OBJECTIVE: To investigate the relationship between bullous pemphigoid (BP) and neurologic disease. DESIGN: Case-control study. SETTING: Tertiary care center for immunobullous diseases and skin tumor clinics at a university hospital in Oxford, England. PARTICIPANTS: Ninety consecutive patients with BP and 141 controls. MAIN OUTCOME MEASURES: Age-adjusted prevalence of neurologic disease in patients and controls. Time interval between the diagnosis of neurologic disease and BP and type of associated neurologic disease. RESULTS: At least 1 neurologic diagnosis was present in 42 patients (46%) compared with 16 controls (11%). Patients had significantly increased odds for neurologic diseases regardless of age and sex (crude odds ratio [OR], 6.8; 95% confidence interval [CI], 3.5-13.3; adjusted OR, 6.2; 95% CI, 3.1-12.4). Four major neurologic diagnoses were observed (cerebrovascular disease, dementia, Parkinson disease, and epilepsy), with statistical significance for cerebrovascular disease and dementia (crude OR for cerebrovascular disease, 6.3; 95% CI, 2.8-14.2; adjusted OR, 6.0; 95% CI, 2.6-13.6; crude OR for dementia, 10.7; 95% CI, 2.3-49.0; adjusted OR, 7.9; 95% CI, 1.7-37.3). When accurate data on time of onset of neurologic disease were present (36 of 42 patients [85%]), BP followed neurologic disease in most patients (26 of 36 patients [72%]), with a median interval of 5.5 years. CONCLUSION: Bullous pemphigoid is significantly associated with cerebrovascular disease and dementia. |
| spellingShingle | Taghipour, K Chi, C Vincent, A Groves, R Venning, V Wojnarowska, F The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. |
| title | The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. |
| title_full | The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. |
| title_fullStr | The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. |
| title_full_unstemmed | The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. |
| title_short | The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. |
| title_sort | association of bullous pemphigoid with cerebrovascular disease and dementia a case control study |
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