Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22.
In order to study the distribution of genes that escape X chromosome inactivation, a high density yeast artificial chromosome (YAC) contig and STS map spanning approximately 6 Mb has been constructed in Xp11.21-p11.22. The contig contains 113 YACs mapped with 53 markers, including 10 genes. Four gen...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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| _version_ | 1797050801861951488 |
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| author | Miller, A Gustashaw, K Wolff, D Rider, S Monaco, A Eble, B Schlessinger, D Gorski, J van Ommen, G Weissenbach, J |
| author_facet | Miller, A Gustashaw, K Wolff, D Rider, S Monaco, A Eble, B Schlessinger, D Gorski, J van Ommen, G Weissenbach, J |
| author_sort | Miller, A |
| collection | OXFORD |
| description | In order to study the distribution of genes that escape X chromosome inactivation, a high density yeast artificial chromosome (YAC) contig and STS map spanning approximately 6 Mb has been constructed in Xp11.21-p11.22. The contig contains 113 YACs mapped with 53 markers, including 10 genes. Four genes have been assayed for their expression status on both the active and inactive human X chromosomes, and these data have been combined with previous results on two other genes in the contig. Three of these genes escape X inactivation and have been localized to a single YAC clone of approximately 1075 kb. The other three genes are subject to inactivation, with two of them lying among the genes that escape inactivation. These results suggest that there are both regional control signals as well as gene-specific elements that determine the X inactivation status of genes on the proximal short arm of the human X chromosome. |
| first_indexed | 2024-03-06T18:10:35Z |
| format | Journal article |
| id | oxford-uuid:02e2ec56-6039-445a-9b28-3861e6e35dff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:10:35Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:02e2ec56-6039-445a-9b28-3861e6e35dff2022-03-26T08:43:10ZThree genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02e2ec56-6039-445a-9b28-3861e6e35dffEnglishSymplectic Elements at Oxford1995Miller, AGustashaw, KWolff, DRider, SMonaco, AEble, BSchlessinger, DGorski, Jvan Ommen, GWeissenbach, JIn order to study the distribution of genes that escape X chromosome inactivation, a high density yeast artificial chromosome (YAC) contig and STS map spanning approximately 6 Mb has been constructed in Xp11.21-p11.22. The contig contains 113 YACs mapped with 53 markers, including 10 genes. Four genes have been assayed for their expression status on both the active and inactive human X chromosomes, and these data have been combined with previous results on two other genes in the contig. Three of these genes escape X inactivation and have been localized to a single YAC clone of approximately 1075 kb. The other three genes are subject to inactivation, with two of them lying among the genes that escape inactivation. These results suggest that there are both regional control signals as well as gene-specific elements that determine the X inactivation status of genes on the proximal short arm of the human X chromosome. |
| spellingShingle | Miller, A Gustashaw, K Wolff, D Rider, S Monaco, A Eble, B Schlessinger, D Gorski, J van Ommen, G Weissenbach, J Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. |
| title | Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. |
| title_full | Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. |
| title_fullStr | Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. |
| title_full_unstemmed | Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. |
| title_short | Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. |
| title_sort | three genes that escape x chromosome inactivation are clustered within a 6 mb yac contig and sts map in xp11 21 p11 22 |
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