Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study.
Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile aft...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1826256967139590144 |
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| author | Brahe, L Ängquist, L Larsen, L Vimaleswaran, K Hager, J Viguerie, N Loos, R Handjieva-Darlenska, T Jebb, SA Hlavaty, P Larsen, T Martinez, J Papadaki, A Pfeiffer, A Baak, v Sørensen, T Holst, C Langin, D Astrup, A Saris, W |
| author_facet | Brahe, L Ängquist, L Larsen, L Vimaleswaran, K Hager, J Viguerie, N Loos, R Handjieva-Darlenska, T Jebb, SA Hlavaty, P Larsen, T Martinez, J Papadaki, A Pfeiffer, A Baak, v Sørensen, T Holst, C Langin, D Astrup, A Saris, W |
| author_sort | Brahe, L |
| collection | OXFORD |
| description | Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect) ,and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of 20.26 mmol/l per A-allele/protein unit (95% CI 20.38, 20.14, P=0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration. |
| first_indexed | 2024-03-06T18:10:41Z |
| format | Journal article |
| id | oxford-uuid:02e97379-aba5-4a6a-bf3c-6a8daa99a162 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:10:41Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:02e97379-aba5-4a6a-bf3c-6a8daa99a1622022-03-26T08:43:20ZInfluence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02e97379-aba5-4a6a-bf3c-6a8daa99a162EnglishSymplectic Elements at Oxford2013Brahe, LÄngquist, LLarsen, LVimaleswaran, KHager, JViguerie, NLoos, RHandjieva-Darlenska, TJebb, SAHlavaty, PLarsen, TMartinez, JPapadaki, APfeiffer, ABaak, vSørensen, THolst, CLangin, DAstrup, ASaris, WBlood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect) ,and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of 20.26 mmol/l per A-allele/protein unit (95% CI 20.38, 20.14, P=0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration. |
| spellingShingle | Brahe, L Ängquist, L Larsen, L Vimaleswaran, K Hager, J Viguerie, N Loos, R Handjieva-Darlenska, T Jebb, SA Hlavaty, P Larsen, T Martinez, J Papadaki, A Pfeiffer, A Baak, v Sørensen, T Holst, C Langin, D Astrup, A Saris, W Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. |
| title | Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. |
| title_full | Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. |
| title_fullStr | Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. |
| title_full_unstemmed | Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. |
| title_short | Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. |
| title_sort | influence of snps in nutrient sensitive candidate genes and gene diet interactions on blood lipids the diogenes study |
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