Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis
Japanese encephalitis is the commonest form of encephalitis globally. Most cases develop characteristic encephalitis but some also present with flaccid paralysis. The paralysis is secondary to damage at the alpha motor neurone, the site that is also damaged in amyotrophic lateral sclerosis (ALS). Th...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1826256967540146176 |
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| author | Thuong, N Dunstan, S Dung, N Charlieu, J Loan, H Wills, B Solomon, T Farrar, J |
| author_facet | Thuong, N Dunstan, S Dung, N Charlieu, J Loan, H Wills, B Solomon, T Farrar, J |
| author_sort | Thuong, N |
| collection | OXFORD |
| description | Japanese encephalitis is the commonest form of encephalitis globally. Most cases develop characteristic encephalitis but some also present with flaccid paralysis. The paralysis is secondary to damage at the alpha motor neurone, the site that is also damaged in amyotrophic lateral sclerosis (ALS). The gene coding for superoxide dismutase 1 (SOD1) is thought to be involved in ALS and may also be linked to susceptibility to Japanese encephalitis. To investigate this possibility, polymorphisms in the SOD1 gene were investigated, in 61 cases of Japanese encephalitis, 61 matched controls and 171 population controls, in Vietnam. Novel polymorphisms, found only in three of the cases and one of the population controls, may be involved with susceptibility to Japanese encephalitis and potentially to other flavivirus infections that lead to damage to the cells of the anterior horn. Further research on this possible association is required. © 2006 The Liverpool School of Tropical Medicine. |
| first_indexed | 2024-03-06T18:10:41Z |
| format | Journal article |
| id | oxford-uuid:02e99780-4b99-4954-9543-1cacbaf09f65 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:10:41Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:02e99780-4b99-4954-9543-1cacbaf09f652022-03-26T08:43:19ZPolymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02e99780-4b99-4954-9543-1cacbaf09f65EnglishSymplectic Elements at Oxford2006Thuong, NDunstan, SDung, NCharlieu, JLoan, HWills, BSolomon, TFarrar, JJapanese encephalitis is the commonest form of encephalitis globally. Most cases develop characteristic encephalitis but some also present with flaccid paralysis. The paralysis is secondary to damage at the alpha motor neurone, the site that is also damaged in amyotrophic lateral sclerosis (ALS). The gene coding for superoxide dismutase 1 (SOD1) is thought to be involved in ALS and may also be linked to susceptibility to Japanese encephalitis. To investigate this possibility, polymorphisms in the SOD1 gene were investigated, in 61 cases of Japanese encephalitis, 61 matched controls and 171 population controls, in Vietnam. Novel polymorphisms, found only in three of the cases and one of the population controls, may be involved with susceptibility to Japanese encephalitis and potentially to other flavivirus infections that lead to damage to the cells of the anterior horn. Further research on this possible association is required. © 2006 The Liverpool School of Tropical Medicine. |
| spellingShingle | Thuong, N Dunstan, S Dung, N Charlieu, J Loan, H Wills, B Solomon, T Farrar, J Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis |
| title | Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis |
| title_full | Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis |
| title_fullStr | Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis |
| title_full_unstemmed | Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis |
| title_short | Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis |
| title_sort | polymorphisms of the gene coding for copper zinc superoxide dismutase sod1 in patients with japanese encephalitis |
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