Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-alpha subunits are rapidly destroyed by a mechanism that involves ubiquitylation by the von Hippel-Lindau tumor suppressor (...

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Bibliografiska uppgifter
Huvudupphovsmän:	Jaakkola, P, Mole, D, Tian, Y, Wilson, M, Gielbert, J, Gaskell, S, von Kriegsheim, A, Hebestreit, H, Mukherji, M, Schofield, C, Maxwell, P, Pugh, C, Ratcliffe, P
Materialtyp:	Journal article
Språk:	English
Publicerad:	2001

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