The structural basis of nuclear function.
Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory"...
| Principais autores: | , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
1995
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| _version_ | 1826256982321922048 |
|---|---|
| author | Jackson, D Cook, P |
| author_facet | Jackson, D Cook, P |
| author_sort | Jackson, D |
| collection | OXFORD |
| description | Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed. |
| first_indexed | 2024-03-06T18:10:55Z |
| format | Journal article |
| id | oxford-uuid:02fd3744-d0db-485b-9ece-acb405a5c0c0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:10:55Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:02fd3744-d0db-485b-9ece-acb405a5c0c02022-03-26T08:43:43ZThe structural basis of nuclear function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:02fd3744-d0db-485b-9ece-acb405a5c0c0EnglishSymplectic Elements at Oxford1995Jackson, DCook, PMost models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed. |
| spellingShingle | Jackson, D Cook, P The structural basis of nuclear function. |
| title | The structural basis of nuclear function. |
| title_full | The structural basis of nuclear function. |
| title_fullStr | The structural basis of nuclear function. |
| title_full_unstemmed | The structural basis of nuclear function. |
| title_short | The structural basis of nuclear function. |
| title_sort | structural basis of nuclear function |
| work_keys_str_mv | AT jacksond thestructuralbasisofnuclearfunction AT cookp thestructuralbasisofnuclearfunction AT jacksond structuralbasisofnuclearfunction AT cookp structuralbasisofnuclearfunction |