Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP
The new and growing family of interleukin-1β-converting enzyme (ICE) cysteine proteases are now recognised to be major effectors of cellular death by apoptosis. Like other members of this family, the CPP32/Yama proform is activated by processing to its active heterodimeric enzyme or apopain when it...
| Hauptverfasser: | , |
|---|---|
| Weitere Verfasser: | |
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
1996
|
| Schlagworte: |