Deciphering the contribution of γδ T cells to outcomes in transplantation
γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct...
| Main Authors: | , , |
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| Format: | Journal article |
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Lippincott Williams and Wilkins
2018
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| _version_ | 1826257005299367936 |
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| author | McCallion, O Hester, J Issa, F |
| author_facet | McCallion, O Hester, J Issa, F |
| author_sort | McCallion, O |
| collection | OXFORD |
| description | γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties. |
| first_indexed | 2024-03-06T18:11:16Z |
| format | Journal article |
| id | oxford-uuid:031a1cf6-108b-4363-a0ef-f5097bffbffc |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:11:16Z |
| publishDate | 2018 |
| publisher | Lippincott Williams and Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:031a1cf6-108b-4363-a0ef-f5097bffbffc2022-03-26T08:44:16ZDeciphering the contribution of γδ T cells to outcomes in transplantationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:031a1cf6-108b-4363-a0ef-f5097bffbffcSymplectic Elements at OxfordLippincott Williams and Wilkins2018McCallion, OHester, JIssa, Fγδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties. |
| spellingShingle | McCallion, O Hester, J Issa, F Deciphering the contribution of γδ T cells to outcomes in transplantation |
| title | Deciphering the contribution of γδ T cells to outcomes in transplantation |
| title_full | Deciphering the contribution of γδ T cells to outcomes in transplantation |
| title_fullStr | Deciphering the contribution of γδ T cells to outcomes in transplantation |
| title_full_unstemmed | Deciphering the contribution of γδ T cells to outcomes in transplantation |
| title_short | Deciphering the contribution of γδ T cells to outcomes in transplantation |
| title_sort | deciphering the contribution of γδ t cells to outcomes in transplantation |
| work_keys_str_mv | AT mccalliono decipheringthecontributionofgdtcellstooutcomesintransplantation AT hesterj decipheringthecontributionofgdtcellstooutcomesintransplantation AT issaf decipheringthecontributionofgdtcellstooutcomesintransplantation |