Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes.
Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1977
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| _version_ | 1797050895906635776 |
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| author | Fox, C Darby, S Ireland, J Sönksen, P |
| author_facet | Fox, C Darby, S Ireland, J Sönksen, P |
| author_sort | Fox, C |
| collection | OXFORD |
| description | Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed. |
| first_indexed | 2024-03-06T18:11:59Z |
| format | Journal article |
| id | oxford-uuid:03588604-79f2-4bc5-a8c4-47056ac2bbd4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:11:59Z |
| publishDate | 1977 |
| record_format | dspace |
| spelling | oxford-uuid:03588604-79f2-4bc5-a8c4-47056ac2bbd42022-03-26T08:45:34ZBlood glucose control and glomerular capillary basement membrane thickening in experimental diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:03588604-79f2-4bc5-a8c4-47056ac2bbd4EnglishSymplectic Elements at Oxford1977Fox, CDarby, SIreland, JSönksen, PGlomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed. |
| spellingShingle | Fox, C Darby, S Ireland, J Sönksen, P Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. |
| title | Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. |
| title_full | Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. |
| title_fullStr | Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. |
| title_full_unstemmed | Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. |
| title_short | Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. |
| title_sort | blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes |
| work_keys_str_mv | AT foxc bloodglucosecontrolandglomerularcapillarybasementmembranethickeninginexperimentaldiabetes AT darbys bloodglucosecontrolandglomerularcapillarybasementmembranethickeninginexperimentaldiabetes AT irelandj bloodglucosecontrolandglomerularcapillarybasementmembranethickeninginexperimentaldiabetes AT sonksenp bloodglucosecontrolandglomerularcapillarybasementmembranethickeninginexperimentaldiabetes |