Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study.
BACKGROUND: To devise treatment strategies for neonatal infections, the population-level incidence and antibiotic susceptibility of pathogens must be defined. METHODS: Surveillance for suspected neonatal sepsis was conducted in Mirzapur, Bangladesh, from February 2004 through November 2006. Communit...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797050960794615808 |
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| author | Darmstadt, G Saha, S Choi, Y El Arifeen, S Ahmed, N Bari, S Rahman, S Mannan, I Crook, D Fatima, K Winch, P Seraji, H Begum, N Rahman, R Islam, M Rahman, A Black, R Santosham, M Sacks, E Baqui, A |
| author_facet | Darmstadt, G Saha, S Choi, Y El Arifeen, S Ahmed, N Bari, S Rahman, S Mannan, I Crook, D Fatima, K Winch, P Seraji, H Begum, N Rahman, R Islam, M Rahman, A Black, R Santosham, M Sacks, E Baqui, A |
| author_sort | Darmstadt, G |
| collection | OXFORD |
| description | BACKGROUND: To devise treatment strategies for neonatal infections, the population-level incidence and antibiotic susceptibility of pathogens must be defined. METHODS: Surveillance for suspected neonatal sepsis was conducted in Mirzapur, Bangladesh, from February 2004 through November 2006. Community health workers assessed neonates on postnatal days 0, 2, 5, and 8 and referred sick neonates to a hospital, where blood was collected for culture from neonates with suspected sepsis. We estimated the incidence and pattern of community-acquired neonatal bacteremia and determined the antibiotic susceptibility profile of pathogens. RESULTS: The incidence rate of community-acquired neonatal bacteremia was 3.0 per 1000 person-neonatal periods. Among the 30 pathogens identified, the most common was Staphylococcus aureus (n = 10); half of all isolates were gram positive. Nine were resistant to ampicillin and gentamicin or to ceftiaxone, and 13 were resistant to cotrimoxazole. CONCLUSION: S. aureus was the most common pathogen to cause community-acquired neonatal bacteremia. Nearly 40% of infections were identified on days 0-3, emphasizing the need to address maternal and environmental sources of infection. The combination of parenteral procaine benzyl penicillin and an aminoglycoside is recommended for the first-line treatment of serious community-acquired neonatal infections in rural Bangladesh, which has a moderate level of neonatal mortality. Additional population-based data are needed to further guide national and global strategies. |
| first_indexed | 2024-03-06T18:12:58Z |
| format | Journal article |
| id | oxford-uuid:03a468af-839c-47d3-8c16-9741400a6833 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:12:58Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:03a468af-839c-47d3-8c16-9741400a68332022-03-26T08:47:27ZPopulation-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:03a468af-839c-47d3-8c16-9741400a6833EnglishSymplectic Elements at Oxford2009Darmstadt, GSaha, SChoi, YEl Arifeen, SAhmed, NBari, SRahman, SMannan, ICrook, DFatima, KWinch, PSeraji, HBegum, NRahman, RIslam, MRahman, ABlack, RSantosham, MSacks, EBaqui, ABACKGROUND: To devise treatment strategies for neonatal infections, the population-level incidence and antibiotic susceptibility of pathogens must be defined. METHODS: Surveillance for suspected neonatal sepsis was conducted in Mirzapur, Bangladesh, from February 2004 through November 2006. Community health workers assessed neonates on postnatal days 0, 2, 5, and 8 and referred sick neonates to a hospital, where blood was collected for culture from neonates with suspected sepsis. We estimated the incidence and pattern of community-acquired neonatal bacteremia and determined the antibiotic susceptibility profile of pathogens. RESULTS: The incidence rate of community-acquired neonatal bacteremia was 3.0 per 1000 person-neonatal periods. Among the 30 pathogens identified, the most common was Staphylococcus aureus (n = 10); half of all isolates were gram positive. Nine were resistant to ampicillin and gentamicin or to ceftiaxone, and 13 were resistant to cotrimoxazole. CONCLUSION: S. aureus was the most common pathogen to cause community-acquired neonatal bacteremia. Nearly 40% of infections were identified on days 0-3, emphasizing the need to address maternal and environmental sources of infection. The combination of parenteral procaine benzyl penicillin and an aminoglycoside is recommended for the first-line treatment of serious community-acquired neonatal infections in rural Bangladesh, which has a moderate level of neonatal mortality. Additional population-based data are needed to further guide national and global strategies. |
| spellingShingle | Darmstadt, G Saha, S Choi, Y El Arifeen, S Ahmed, N Bari, S Rahman, S Mannan, I Crook, D Fatima, K Winch, P Seraji, H Begum, N Rahman, R Islam, M Rahman, A Black, R Santosham, M Sacks, E Baqui, A Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. |
| title | Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. |
| title_full | Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. |
| title_fullStr | Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. |
| title_full_unstemmed | Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. |
| title_short | Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. |
| title_sort | population based incidence and etiology of community acquired neonatal bacteremia in mirzapur bangladesh an observational study |
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