Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

Collagen degradation and proMMP-2 activation are major functions of MT1-MMP to promote cancer cell invasion. Since both processes require MT1-MMP homodimerization on the cell surface, herein we propose that the use of bifunctional inhibitors of this enzyme could represent an innovative approach to e...

Bibliográfalaš dieđut
Váldodahkkit:	Cuffaro, D, Nuti, E, Gifford, V, Ito, N, Camodeca, C, Tuccinardi, T, Nencetti, S, Orlandini, E, Itoh, Y, Rossello, A
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Elsevier 2018

Geahča maid

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease
Dahkki: Lidia Ciccone, et al.
Almmustuhtton: (2021-01-01)

MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion.
Dahkki: Woskowicz, A, et al.
Almmustuhtton: (2013)

Dynamic Expression of Membrane Type 1-Matrix Metalloproteinase (Mt1-mmp/Mmp14) in the Mouse Embryo
Dahkki: Emma Muñoz-Sáez, et al.
Almmustuhtton: (2021-09-01)

Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells
Dahkki: Gifford, V, et al.
Almmustuhtton: (2022)

Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.
Dahkki: Itoh, Y, et al.
Almmustuhtton: (1999)

Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP.
Dahkki: Kojima, S, et al.
Almmustuhtton: (2000)

Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
Dahkki: Zhao, H, et al.
Almmustuhtton: (2004)

Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele
Dahkki: Fujita, M, et al.
Almmustuhtton: (2001)

Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP, MMP14) in Eutopic and Ectopic Endometrium and in Serum and Endocervical Mucus of Endometriosis
Dahkki: Jane B. Maoga, et al.
Almmustuhtton: (2023-10-01)

Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
Dahkki: Bai, S, et al.
Almmustuhtton: (2005)

CD44 directs membrane-type 1 matrix metalloproteinase (MT1-MMP) to lamellipodia by associating with its hemopexin-like domain (PEX)
Dahkki: Mori, H, et al.
Almmustuhtton: (2002)

Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts.
Dahkki: Kajita, M, et al.
Almmustuhtton: (1999)

Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.
Dahkki: María José Blanco, et al.
Almmustuhtton: (2017-01-01)

Cell surface localization of MT1-MMP to the matrix attachment site: Effect of CD44 and MT-Loop region of MT1-MMP
Dahkki: Woskowicz, A, et al.
Almmustuhtton: (2010)

Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.
Dahkki: Manakan B Srichai, et al.
Almmustuhtton: (2011-02-01)

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
Dahkki: Gifford, V, et al.
Almmustuhtton: (2019)

Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking.
Dahkki: Jian Li, et al.
Almmustuhtton: (2012-01-01)

N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Dahkki: Nuti, E, et al.
Almmustuhtton: (2009)

Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma
Dahkki: Bettina Hieronimus, et al.
Almmustuhtton: (2017-05-01)

Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.
Dahkki: Itoh, Y, et al.
Almmustuhtton: (2006)

Homophilic complex formation of MT1-matrix metalloproteinase is essential to express collagenolytic activity on the cell surface
Dahkki: Itoh, Y, et al.
Almmustuhtton: (2005)

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion.
Dahkki: Olga Tatti, et al.
Almmustuhtton: (2011-01-01)

A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells.
Dahkki: Delphine Assent, et al.
Almmustuhtton: (2015-01-01)

MT1-MMP: an enzyme with multidimensional regulation.
Dahkki: Itoh, Y, et al.
Almmustuhtton: (2004)

Analyses of MT1-MMP activity in cells.
Dahkki: Evans, R, et al.
Almmustuhtton: (2007)

Spatial regulation of MT1-MMP controls tubulogenesis of epithelial cells in a 3D collagen matrix
Dahkki: Bird-Weaver, S, et al.
Almmustuhtton: (2010)

Structural requirements for collagenolytic activity of matrix metalloproteinase 1 (MMP-1)
Dahkki: Chung, L, et al.
Almmustuhtton: (2000)

Membrane-type 1 matrix metalloproteinase and cell migration.
Dahkki: Seiki, M, et al.
Almmustuhtton: (2003)

Immunoexpression of matrix metalloproteinases MMP-1, MMP-2, MMP-9 and MMP-14 in extragenital endometriosis and eutopic endometrium
Dahkki: Eugeniu Cazacu, et al.
Almmustuhtton: (2020-10-01)

Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix
Dahkki: Weaver, SA, et al.
Almmustuhtton: (2014)

Intracellular trafficking of the invasion-promoting cell surface proteinase MT1-MMP
Dahkki: Gifford, V
Almmustuhtton: (2020)

Kinetic characterization of new selective collagenase 3 (MMP-13) inhibitors as potential therapeutic agents in osteoarthritis
Dahkki: Santamaria, S, et al.
Almmustuhtton: (2009)

Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Dahkki: Nonaka, T, et al.
Almmustuhtton: (2005)

Delving into Matrix Metalloproteinase-1 (MMP-1) and its Significance in Periodontal Diseases
Dahkki: Natarajan Prabhu M, et al.
Almmustuhtton: (2024-04-01)

“Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
Dahkki: Gabriela D'Amico, et al.
Almmustuhtton: (2019-12-01)

The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.
Dahkki: Itoh, Y, et al.
Almmustuhtton: (2008)

Matrix metalloproteinases (MMP-1, -8, -13) in chronic periapical lesions
Dahkki: Andonovska Biljana, et al.
Almmustuhtton: (2008-01-01)

Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis
Dahkki: Rajendran R, et al.
Almmustuhtton: (2006-01-01)

MT1-MMP: a potent modifier of pericellular microenvironment.
Dahkki: Itoh, Y, et al.
Almmustuhtton: (2006)

MT1-MMP: a key regulator of cell migration in tissue.
Dahkki: Itoh, Y
Almmustuhtton: (2006)