Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

Collagen degradation and proMMP-2 activation are major functions of MT1-MMP to promote cancer cell invasion. Since both processes require MT1-MMP homodimerization on the cell surface, herein we propose that the use of bifunctional inhibitors of this enzyme could represent an innovative approach to e...

书目详细资料
Main Authors:	Cuffaro, D, Nuti, E, Gifford, V, Ito, N, Camodeca, C, Tuccinardi, T, Nencetti, S, Orlandini, E, Itoh, Y, Rossello, A
格式:	Journal article
语言:	English
出版:	Elsevier 2018

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