Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease.
The contribution of autoimmune responses to the pathogenesis of Theiler's virus-induced demyelinating disease was investigated. Delayed-type hypersensitivity responses to myelin were examined in both symptomatic and asymptomatic mice at different times post-infection, in order to determine whet...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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| _version_ | 1826257131951620096 |
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| author | Borrow, P Welsh, C Tonks, P Dean, D Blakemore, W Nash, A |
| author_facet | Borrow, P Welsh, C Tonks, P Dean, D Blakemore, W Nash, A |
| author_sort | Borrow, P |
| collection | OXFORD |
| description | The contribution of autoimmune responses to the pathogenesis of Theiler's virus-induced demyelinating disease was investigated. Delayed-type hypersensitivity responses to myelin were examined in both symptomatic and asymptomatic mice at different times post-infection, in order to determine whether autoreactivity correlates with the development of demyelination. The results indicate that although autoimmune responses probably do not play a major role in the initiation of demyelination at early times post-infection, autoreactivity to myelin antigens dose eventually develop in symptomatic animals, perhaps through the mechanism of epitope spreading. Autoimmunity to myelin components is therefore an additional factor that may contribute to lesion progression in chronically diseased animals. |
| first_indexed | 2024-03-06T18:13:16Z |
| format | Journal article |
| id | oxford-uuid:03c0414e-fdb3-497b-abc8-788b0d638341 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:13:16Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:03c0414e-fdb3-497b-abc8-788b0d6383412022-03-26T08:47:59ZInvestigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:03c0414e-fdb3-497b-abc8-788b0d638341EnglishSymplectic Elements at Oxford1998Borrow, PWelsh, CTonks, PDean, DBlakemore, WNash, AThe contribution of autoimmune responses to the pathogenesis of Theiler's virus-induced demyelinating disease was investigated. Delayed-type hypersensitivity responses to myelin were examined in both symptomatic and asymptomatic mice at different times post-infection, in order to determine whether autoreactivity correlates with the development of demyelination. The results indicate that although autoimmune responses probably do not play a major role in the initiation of demyelination at early times post-infection, autoreactivity to myelin antigens dose eventually develop in symptomatic animals, perhaps through the mechanism of epitope spreading. Autoimmunity to myelin components is therefore an additional factor that may contribute to lesion progression in chronically diseased animals. |
| spellingShingle | Borrow, P Welsh, C Tonks, P Dean, D Blakemore, W Nash, A Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease. |
| title | Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease. |
| title_full | Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease. |
| title_fullStr | Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease. |
| title_full_unstemmed | Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease. |
| title_short | Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease. |
| title_sort | investigation of the role of delayed type hypersensitivity responses to myelin in the pathogenesis of theiler s virus induced demyelinating disease |
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