Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.
The serum concentrations of the complement inactivators C1INH, C3bINA and beta 1H have been determined in patients with ulcerative colitis and Crohn's disease and their correlation with C3 and properdin factor B examined. The incidence of immunoconglutinins (1K) in these patients was investigat...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1980
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| _version_ | 1826257169645830144 |
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| author | Potter, B Brown, D Watson, A Jewell, D |
| author_facet | Potter, B Brown, D Watson, A Jewell, D |
| author_sort | Potter, B |
| collection | OXFORD |
| description | The serum concentrations of the complement inactivators C1INH, C3bINA and beta 1H have been determined in patients with ulcerative colitis and Crohn's disease and their correlation with C3 and properdin factor B examined. The incidence of immunoconglutinins (1K) in these patients was investigated. Raised serum concentrations of C1INH and C3bINA have been found in patients with active disease, but no significant alteration was found in serum concentration of beta 1H. An increasing incidence of positive 1K titres was found with increased length of disease history. These results suggest continuing complement activation in these diseases. |
| first_indexed | 2024-03-06T18:13:52Z |
| format | Journal article |
| id | oxford-uuid:03ee9a9f-b197-4fd3-a911-fb8b7b1062a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:13:52Z |
| publishDate | 1980 |
| record_format | dspace |
| spelling | oxford-uuid:03ee9a9f-b197-4fd3-a911-fb8b7b1062a62022-03-26T08:49:05ZComplement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:03ee9a9f-b197-4fd3-a911-fb8b7b1062a6EnglishSymplectic Elements at Oxford1980Potter, BBrown, DWatson, AJewell, DThe serum concentrations of the complement inactivators C1INH, C3bINA and beta 1H have been determined in patients with ulcerative colitis and Crohn's disease and their correlation with C3 and properdin factor B examined. The incidence of immunoconglutinins (1K) in these patients was investigated. Raised serum concentrations of C1INH and C3bINA have been found in patients with active disease, but no significant alteration was found in serum concentration of beta 1H. An increasing incidence of positive 1K titres was found with increased length of disease history. These results suggest continuing complement activation in these diseases. |
| spellingShingle | Potter, B Brown, D Watson, A Jewell, D Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease. |
| title | Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease. |
| title_full | Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease. |
| title_fullStr | Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease. |
| title_full_unstemmed | Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease. |
| title_short | Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease. |
| title_sort | complement inhibitors and immunoconglutinins in ulcerative colitis and crohn s disease |
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