Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials.
OBJECTIVE: The authors sought to determine the efficacy and acceptability of lithium for relapse prevention in bipolar disorder. METHOD: A systematic review and meta-analysis of randomized controlled trials comparing lithium with placebo in the long-term treatment of bipolar disorders was conducted...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797051043175989248 |
|---|---|
| author | Geddes, J Burgess, S Hawton, K Jamison, K Goodwin, G |
| author_facet | Geddes, J Burgess, S Hawton, K Jamison, K Goodwin, G |
| author_sort | Geddes, J |
| collection | OXFORD |
| description | OBJECTIVE: The authors sought to determine the efficacy and acceptability of lithium for relapse prevention in bipolar disorder. METHOD: A systematic review and meta-analysis of randomized controlled trials comparing lithium with placebo in the long-term treatment of bipolar disorders was conducted. Data were obtained from searching the registers of the Cochrane Collaboration; reviewing reference lists, journals, and conference abstracts; and contacting authors, experts, and pharmaceutical companies. Outcomes investigated included risk of relapse (manic, depressive, and total) as well as risk of specific adverse effects and total withdrawal rates. RESULTS: Five randomized controlled trials (770 participants) were included. Lithium was more effective than placebo in preventing all relapses (random effects relative risk=0.65, 95% CI=0.50 to 0.84) and manic relapses (relative risk=0.62, 95% CI=0.40 to 0.95). The protective effect of lithium on depressive relapses was smaller and was less robust (relative risk=0.72, 95% CI=0.49 to 1.07). CONCLUSIONS: Lithium treatment reduces the risk of relapse in bipolar disorder. The preventive effect is clear for manic episodes, although it is equivocal for depressive episodes. |
| first_indexed | 2024-03-06T18:14:12Z |
| format | Journal article |
| id | oxford-uuid:040cf7ba-2b05-4d15-a9c7-c335f7b2a8de |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:14:12Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:040cf7ba-2b05-4d15-a9c7-c335f7b2a8de2022-03-26T08:49:45ZLong-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:040cf7ba-2b05-4d15-a9c7-c335f7b2a8deEnglishSymplectic Elements at Oxford2004Geddes, JBurgess, SHawton, KJamison, KGoodwin, G OBJECTIVE: The authors sought to determine the efficacy and acceptability of lithium for relapse prevention in bipolar disorder. METHOD: A systematic review and meta-analysis of randomized controlled trials comparing lithium with placebo in the long-term treatment of bipolar disorders was conducted. Data were obtained from searching the registers of the Cochrane Collaboration; reviewing reference lists, journals, and conference abstracts; and contacting authors, experts, and pharmaceutical companies. Outcomes investigated included risk of relapse (manic, depressive, and total) as well as risk of specific adverse effects and total withdrawal rates. RESULTS: Five randomized controlled trials (770 participants) were included. Lithium was more effective than placebo in preventing all relapses (random effects relative risk=0.65, 95% CI=0.50 to 0.84) and manic relapses (relative risk=0.62, 95% CI=0.40 to 0.95). The protective effect of lithium on depressive relapses was smaller and was less robust (relative risk=0.72, 95% CI=0.49 to 1.07). CONCLUSIONS: Lithium treatment reduces the risk of relapse in bipolar disorder. The preventive effect is clear for manic episodes, although it is equivocal for depressive episodes. |
| spellingShingle | Geddes, J Burgess, S Hawton, K Jamison, K Goodwin, G Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. |
| title | Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. |
| title_full | Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. |
| title_fullStr | Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. |
| title_full_unstemmed | Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. |
| title_short | Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. |
| title_sort | long term lithium therapy for bipolar disorder systematic review and meta analysis of randomized controlled trials |
| work_keys_str_mv | AT geddesj longtermlithiumtherapyforbipolardisordersystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT burgesss longtermlithiumtherapyforbipolardisordersystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT hawtonk longtermlithiumtherapyforbipolardisordersystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT jamisonk longtermlithiumtherapyforbipolardisordersystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT goodwing longtermlithiumtherapyforbipolardisordersystematicreviewandmetaanalysisofrandomizedcontrolledtrials |