Bisphosphonates and bone quality.
Bisphosphonates (BPs) are bone-avid compounds used as first-line medications for the prevention and treatment of osteoporosis. They are also used in other skeletal pathologies such as Paget's and metastatic bone disease. They effectively reduce osteoclast viability and also activity in the reso...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797051064606785536 |
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| author | Pazianas, M van der Geest, S Miller, P |
| author_facet | Pazianas, M van der Geest, S Miller, P |
| author_sort | Pazianas, M |
| collection | OXFORD |
| description | Bisphosphonates (BPs) are bone-avid compounds used as first-line medications for the prevention and treatment of osteoporosis. They are also used in other skeletal pathologies such as Paget's and metastatic bone disease. They effectively reduce osteoclast viability and also activity in the resorptive phase of bone remodelling and help preserve bone micro-architecture, both major determinants of bone strength and ultimately of the susceptibility to fractures. The chemically distinctive structure of each BP used in the clinic determines their unique affinity, distribution/penetration throughout the bone and their individual effects on bone geometry, micro-architecture and composition or what we call 'bone quality'. BPs have no clinically significant anabolic effects. This review will touch upon some of the components of bone quality that could be affected by the administration of BPs. |
| first_indexed | 2024-03-06T18:14:31Z |
| format | Journal article |
| id | oxford-uuid:04286407-5679-4a3e-b06e-1d3fd071c433 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:14:31Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:04286407-5679-4a3e-b06e-1d3fd071c4332022-03-26T08:50:17ZBisphosphonates and bone quality.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:04286407-5679-4a3e-b06e-1d3fd071c433EnglishSymplectic Elements at Oxford2014Pazianas, Mvan der Geest, SMiller, PBisphosphonates (BPs) are bone-avid compounds used as first-line medications for the prevention and treatment of osteoporosis. They are also used in other skeletal pathologies such as Paget's and metastatic bone disease. They effectively reduce osteoclast viability and also activity in the resorptive phase of bone remodelling and help preserve bone micro-architecture, both major determinants of bone strength and ultimately of the susceptibility to fractures. The chemically distinctive structure of each BP used in the clinic determines their unique affinity, distribution/penetration throughout the bone and their individual effects on bone geometry, micro-architecture and composition or what we call 'bone quality'. BPs have no clinically significant anabolic effects. This review will touch upon some of the components of bone quality that could be affected by the administration of BPs. |
| spellingShingle | Pazianas, M van der Geest, S Miller, P Bisphosphonates and bone quality. |
| title | Bisphosphonates and bone quality. |
| title_full | Bisphosphonates and bone quality. |
| title_fullStr | Bisphosphonates and bone quality. |
| title_full_unstemmed | Bisphosphonates and bone quality. |
| title_short | Bisphosphonates and bone quality. |
| title_sort | bisphosphonates and bone quality |
| work_keys_str_mv | AT pazianasm bisphosphonatesandbonequality AT vandergeests bisphosphonatesandbonequality AT millerp bisphosphonatesandbonequality |