Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
The ability of rat monoclonal antibodies to promote antibody-dependent cell-mediated cytotoxicity with human effector cells was tested by using a variety of antibodies against different human and mouse leukocyte antigens. It was found that only IgG2b antibodies were effective. This isotype has alrea...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1985
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| _version_ | 1797051085497565184 |
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| author | Hale, G Clark, M Waldmann, H |
| author_facet | Hale, G Clark, M Waldmann, H |
| author_sort | Hale, G |
| collection | OXFORD |
| description | The ability of rat monoclonal antibodies to promote antibody-dependent cell-mediated cytotoxicity with human effector cells was tested by using a variety of antibodies against different human and mouse leukocyte antigens. It was found that only IgG2b antibodies were effective. This isotype has already been shown to be efficient in fixing human complement, which suggests that among rat monoclonal antibodies, the IgG2b subclass might be a good choice for attempts at serotherapy. Further studies with other antibody-mediated effector mechanisms as well as suitable clinical trials are merited. |
| first_indexed | 2024-03-06T18:14:50Z |
| format | Journal article |
| id | oxford-uuid:044303a6-3033-42b5-b74d-98262491c747 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:14:50Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:044303a6-3033-42b5-b74d-98262491c7472022-03-26T08:50:51ZTherapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:044303a6-3033-42b5-b74d-98262491c747EnglishSymplectic Elements at Oxford1985Hale, GClark, MWaldmann, HThe ability of rat monoclonal antibodies to promote antibody-dependent cell-mediated cytotoxicity with human effector cells was tested by using a variety of antibodies against different human and mouse leukocyte antigens. It was found that only IgG2b antibodies were effective. This isotype has already been shown to be efficient in fixing human complement, which suggests that among rat monoclonal antibodies, the IgG2b subclass might be a good choice for attempts at serotherapy. Further studies with other antibody-mediated effector mechanisms as well as suitable clinical trials are merited. |
| spellingShingle | Hale, G Clark, M Waldmann, H Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. |
| title | Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. |
| title_full | Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. |
| title_fullStr | Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. |
| title_full_unstemmed | Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. |
| title_short | Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. |
| title_sort | therapeutic potential of rat monoclonal antibodies isotype specificity of antibody dependent cell mediated cytotoxicity with human lymphocytes |
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