Tissue sodium content and arterial hypertension in obese adolescents
Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and hypertension have been observed in adults. We aime...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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MDPI
2019
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| _version_ | 1797051143049707520 |
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| author | Roth, S Markó, L Birukov, A Hennemuth, A Kühnen, P Jones, A Ghorbani, N Linz, P Müller, DN Wiegand, S Berger, F Kuehne, T Kelm, M |
| author_facet | Roth, S Markó, L Birukov, A Hennemuth, A Kühnen, P Jones, A Ghorbani, N Linz, P Müller, DN Wiegand, S Berger, F Kuehne, T Kelm, M |
| author_sort | Roth, S |
| collection | OXFORD |
| description | Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and hypertension have been observed in adults. We aimed to investigate these associations in adolescents. A cohort of 32 adolescents (13–17 years), comprising 20 obese patients, of whom 11 were hypertensive, as well as 12 age-matched controls, underwent 23Na-MRI of the left lower leg with a standard clinical 3T scanner. Median triceps surae muscle Na+ content in hypertensive obese (11.95 mmol/L [interquartile range 11.62–13.66]) was significantly lower than in normotensive obese (13.63 mmol/L [12.97–17.64]; p = 0.043) or controls (15.37 mmol/L [14.12–16.08]; p = 0.012). No significant differences were found between normotensive obese and controls. Skin Na+ content in hypertensive obese (13.33 mmol/L [11.53–14.22] did not differ to normotensive obese (14.12 mmol/L [13.15–15.83]) or controls (11.48 mmol/L [10.48–12.80]), whereas normotensive obese had higher values compared to controls (p = 0.004). Arterial hypertension in obese adolescents is associated with low muscle Na+ content. These findings suggest an early dysregulation of Na+ homeostasis in cardiometabolic disease. Further research is needed to determine whether this association is causal and how it evolves in the transition to adulthood. |
| first_indexed | 2024-03-06T18:15:42Z |
| format | Journal article |
| id | oxford-uuid:048ae08e-7a96-42f7-b791-4fa7806f8ce2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:15:42Z |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:048ae08e-7a96-42f7-b791-4fa7806f8ce22022-03-26T08:52:24ZTissue sodium content and arterial hypertension in obese adolescentsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:048ae08e-7a96-42f7-b791-4fa7806f8ce2EnglishSymplectic ElementsMDPI2019Roth, SMarkó, LBirukov, AHennemuth, AKühnen, PJones, AGhorbani, NLinz, PMüller, DNWiegand, SBerger, FKuehne, TKelm, MEarly-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and hypertension have been observed in adults. We aimed to investigate these associations in adolescents. A cohort of 32 adolescents (13–17 years), comprising 20 obese patients, of whom 11 were hypertensive, as well as 12 age-matched controls, underwent 23Na-MRI of the left lower leg with a standard clinical 3T scanner. Median triceps surae muscle Na+ content in hypertensive obese (11.95 mmol/L [interquartile range 11.62–13.66]) was significantly lower than in normotensive obese (13.63 mmol/L [12.97–17.64]; p = 0.043) or controls (15.37 mmol/L [14.12–16.08]; p = 0.012). No significant differences were found between normotensive obese and controls. Skin Na+ content in hypertensive obese (13.33 mmol/L [11.53–14.22] did not differ to normotensive obese (14.12 mmol/L [13.15–15.83]) or controls (11.48 mmol/L [10.48–12.80]), whereas normotensive obese had higher values compared to controls (p = 0.004). Arterial hypertension in obese adolescents is associated with low muscle Na+ content. These findings suggest an early dysregulation of Na+ homeostasis in cardiometabolic disease. Further research is needed to determine whether this association is causal and how it evolves in the transition to adulthood. |
| spellingShingle | Roth, S Markó, L Birukov, A Hennemuth, A Kühnen, P Jones, A Ghorbani, N Linz, P Müller, DN Wiegand, S Berger, F Kuehne, T Kelm, M Tissue sodium content and arterial hypertension in obese adolescents |
| title | Tissue sodium content and arterial hypertension in obese adolescents |
| title_full | Tissue sodium content and arterial hypertension in obese adolescents |
| title_fullStr | Tissue sodium content and arterial hypertension in obese adolescents |
| title_full_unstemmed | Tissue sodium content and arterial hypertension in obese adolescents |
| title_short | Tissue sodium content and arterial hypertension in obese adolescents |
| title_sort | tissue sodium content and arterial hypertension in obese adolescents |
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